联合检测外周血T淋巴亚群指标CD3^(+)、CD4^(+)、CD8^(+)及CD4^(+)/CD8^(+)对临床早期识别神经梅毒的价值分析  

Analysis of the Value of Combined Detection of Peripheral Blood T-lymphocyte Subpopulation Indicators CD3^(+),CD4^(+),CD8^(+),and CD4^(+)/CD8^(+)in Early Clinical Identification of Neurosyphilis

作　　者：孙冉 Sun Ran(Department of STD and AIDS Prevention and Control,Zhenping County Center for Disease Control and Prevention,Nanyang,Henan,474250,China)

机构地区：[1]河南省镇平县疾病预防控制中心性病艾滋病防治科,河南镇平474250

出　　处：《黑龙江医学》2024年第17期2115-2118,共4页Heilongjiang Medical Journal

摘　　要：目的:分析外周血T淋巴亚群指标CD3^(+)、CD4^(+)、CD8^(+)及CD4^(+)/CD8^(+)在神经梅毒中的早期识别价值。方法:选取2021年4月—2023年4月河南省镇平县疾病预防控制中心收治的98例梅毒患者作为研究对象,按照其是否存在神经系统累及将其分为神经梅毒组(n=41)与非神经梅毒组(n=57);另将同期于疾病预防控制中心行体检的87例健康人纳入健康组,采集3组受试者静脉血,检测对比其CD3^(+)、CD4^(+)、CD8^(+)及CD4^(+)/CD8^(+)之间的差异;另绘制受试者工作曲线(ROC),分析联合检验CD3^(+)、CD4^(+)、CD8^(+)及CD4^(+)/CD8^(+)在神经梅毒患者早期识别中的效能。结果:神经梅毒组的CD3^(+)低于非神经梅毒组与健康组,CD8^(+)高于非神经梅毒组与健康组,且非神经梅毒组的CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)低于健康组,CD8^(+)高于健康组,差异有统计学意义(F=216.471、241.513、151.950、186.240,P<0.05);ROC结果显示,CD3^(+)、CD4^(+)、CD8^(+)及CD4^(+)/CD8^(+)联合检测识别神经梅毒的曲线下面积(AUC)为0.903,高于四者单独检测的0.866、0.845、0.870、0.715。结论:神经梅毒患者体内的CD3^(+)、CD4^(+)、CD8^(+)及CD4^(+)/CD8^(+)呈异常表达,四者联合能够早期识别出神经梅毒,可为临床提供一定的参考信息,具有一定的应用价值。Objective:To analyze the early recognition value of peripheral blood T lymphocyte subpopulation indicators CD3^(+),CD4^(+),CD8^(+),and CD4^(+)/CD8^(+)in neurosyphilis.Methods:98 syphilis patients admitted to the hospital from April 2021 to April 2023 were selected,and all patients were divided into neurosyphilis group(n=41)and non neurosyphilis group(n=57)based on their presence of neurological involvement.In addition,87 healthy individuals who underwent physical examinations in the hospital during the same period were included in the health group.Three groups of venous blood were collected and compared for differences in CD3^(+),CD4^(+),CD8^(+),and CD4^(+)/CD8^(+).Additionally,receiver operating curve(ROC)was drawn to analyze the efficacy of joint testing of CD3^(+),CD4^(+),CD8^(+),and CD4^(+)/CD8^(+)in early recognition of neurosyphilis patients.Results:CD3^(+)in neurosyphilis group was lower than that in non-neurosyphilis group and healthy group,CD8^(+)was higher than that in non-neurosyphilis group and healthy group,CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)in non-neurosyphilis group was lower than that in healthy group,and CD8^(+)was higher than that in healthy group.The difference was statistically significant(F=216.471,241.513,151.950,186.240;P<0.05).Results of ROC showed that the area under the curve(AUC)of the combined detection of CD3^(+),CD4^(+),CD8^(+)and CD4^(+)/CD8^(+)was 0.903,which was higher than that of 0.866,0.845,0.870,0.715.Conclusion:CD3^(+),CD4^(+),CD8^(+),and CD4^(+)/CD8^(+)are abnormally expressed in patients with neurosyphilis.The combination of the four can identify neurosyphilis in the early stage and provide certain reference information for clinical practice.It has certain application value.

关 键 词：神经梅毒 T淋巴亚群 受试者工作曲线 曲线下面积 

分 类 号：R185[医药卫生—流行病学]