糖尿病自身免疫抗体联合检测在糖尿病分型中的应用价值  

Application Value of Combined Detection of Diabetic Autoimmune Antibodies in the Classification of Diabetes Mellitus

作　　者：万志东 于荣 卢景宜 刘淑华[1] WAN Zhidong;YU Rong;LU Jingyi;LIU Shuhua(Department of Medical Laboratory,Dongguan Hospital Guangzhou University of Chinese Medicine/Dongguan Hospital of Traditional Chinese Medicine,Dongguan Guangdong 523000,China)

机构地区：[1]广州中医药大学东莞医院/东莞市中医院医学检验科,广东东莞523000

出　　处：《中国卫生标准管理》2024年第17期131-134,共4页China Health Standard Management

摘　　要：目的分析糖尿病自身免疫抗体联合检测在糖尿病分型中的应用价值。方法将2021年1月—2023年11月于东莞市中医院进行诊治的64例糖尿病患者纳为研究组,其中1型糖尿病(type 1 diabetes mellitus,T1DM)患者22例,2型糖尿病(type 2 diabetes mellitus,T2DM)患者42例。同期体检健康者61例纳为对照组,2组均接受糖尿病自身免疫抗体检测,比较2组的抗体差异性,以及其在糖尿病分型中的价值。结果研究组血清谷氨酸脱羧酶抗体(glutamic acid decarboxylase antibody,GADA)、胰岛细胞抗体(islet cell antibody,ICA)、胰岛素自身抗体(insulin autoantibodies,IAA)以及联合检测阳性率高于对照组,差异有统计学意义(P<0.05);T1DM患者GADA、ICA、IAA以及联合检测阳性率高于T2DM患者,差异有统计学意义(P<0.05);T1DM、T2DM诊断中联合检测的应用价值高于单一抗体检测。结论糖尿病自身免疫抗体联合检测有助于临床更好地鉴别糖尿病分型,为后续治疗提供有价值的指导。Objective To analyze the application value of combined detection of diabetic autoimmune antibodies in diabetes classification.Methods A total of 64 diabetic patients diagnosed and treated in Dongguan Hospital of Traditional Chinese Medicine from January 2021 to November 2023 were included in the study group,incluing 22 patients with type 1 diabetes mellitus(T1DM),42 patients with type 2 diabetes mellitus(T2DM)and 61 healthy patients were included in the control group during the same period.Both two groups were tested for diabetes classification antibodies.The difference of the antibody between the two group and its value in diabetes classification were compered.Results The positive rates of serum glutamic acid decarboxylase antibody(GADA),islet cell antibody(ICA),insulin autoantibodies(IAA)and their combined detection in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).The positive rates of ICA,IAA and the combined test of T1DM patients were higher than those of T2DM patients,and the difference were statistically significant(P<0.05),and the application value of the combined test in the diagnosis of T1DM,T2DM was higher than that of single antibody test.Conclusion The combined detection of diabetic autoimmune antibodies can help to better identify the types of diabetes mellitus in clinical practice and provide valuable guidance for subsequent treatment.

关 键 词：糖尿病分型 谷氨酸脱羧酶抗体 胰岛细胞抗体 胰岛素自身抗体 灵敏度 特异度 

分 类 号：R445[医药卫生—影像医学与核医学]