板蓝根颗粒治疗鼻咽癌患者急性放射性口腔黏膜炎的效果  

The Effect of Banlangen Granules in the Treatment of Acute Radiation-induced Oral Mucositis in Nasopharyngeal Carcinoma Patients

作　　者：何红红 刘勇 吴伟 刘晓云 林松焕 黄立 康敏礼 郑高崟 丁金泉 HE Honghong;LIU Yong;WU Wei;LIU Xiaoyun;LIN Songhuan;HUANG Li;KANG Minli;ZHENG Gaoyin;DING Jinquan(Department of Radiation Therapy,Ganzhou Cancer Hospital,Ganzhou 341000,China;不详)

机构地区：[1]赣州市肿瘤医院肿瘤放射治疗科,江西赣州341000

出　　处：《中国医学创新》2024年第27期85-89,共5页Medical Innovation of China

基　　金：江西省中医药管理局科技项目(SZYYB20217097)。

摘　　要：目的:分析板蓝根颗粒治疗鼻咽癌患者急性放射性口腔黏膜炎的效果。方法:选取赣州市肿瘤医院2021年6月—2024年4月收治的鼻咽癌急性放射性口腔黏膜炎患者60例为研究对象,按照随机数字表法分为对照组(n=30)、试验组(n=30)。对照组给予放疗及常规治疗,试验组给予放疗、常规治疗及板蓝根颗粒。评估对比两组临床疗效、中医症候积分、生活质量、口腔疼痛程度、血清缺氧诱导因子-1α(hypoxia inducible factor-1α,HIF-1α)、促肾上腺皮质激素(adrenocorticotropic hormone,ACTH)水平。结果:与对照组相比,试验组总有效率较高(P<0.05)。治疗前,两组中医症候积分、卡氏功能状态(Karnofsky performance status,KPS)、疼痛数字评分法(numeric rating scale,NRS)评分、血清HIF-1α、ACTH水平对比,差异均无统计学意义(P>0.05);治疗后,两组中医症候积分、NRS评分、血清HIF-1α、ACTH水平均较治疗前降低,且试验组均较低;KPS评分均升高,且试验组较高(P<0.05)。结论:鼻咽癌急性放射性口腔黏膜炎患者采用板蓝根颗粒治疗后临床症状改善,疼痛缓解,生活质量提升,血清HIF-1α、ACTH水平降低。Objective:To analyze the efficacy of Banlangen Granules in the treatment of acute radiationinduced oral mucositis in patients with nasopharyngeal carcinoma.Method:A total of sixty patients with acute radiation-induced oral mucositis of nasopharyngeal carcinoma admitted to Ganzhou Cancer Hospital from June 2021 to April 2024 were selected as the research subjects,they were divided into a control group(n=30),and an experimental group(n=30)by random number table method.The control group received radiotherapy and conventional treatment,the experimental group received radiotherapy,conventional treatment,and Banlangen Granules.The clinical efficacy,traditional Chinese medicine symptom scores,quality of life,degree of oral pain,serum hypoxia inducible factor-1α(HIF-1α),and adrenocorticotropic hormone(ACTH)levels between two groups were evaluated and compared.Result:Compared with the control group,total effective rate in the experimental group was higher(P<0.05).Before treatment,traditional Chinese medicine symptom scores,Karnofsky performance status(KPS),numerical rating scale(NRS)scores,and serum levels of HIF-1αand ACTH between the two groups,the differences were not statistically significant(P>0.05);after treatment,the levels of TCM syndrome score,NRS score,serum HIF-1αand ACTH in the two groups were decreased compared to those before treatment,and the experimental group were lower;and the KPS score was increased,and the experimental group was higher(P<0.05).Conclusion:After treatment with Banlangen Granules,patients with acute radiation-induced oral mucositis of nasopharyngeal carcinoma show improvement in clinical symptoms,pain relief and quality of life,and decrease in serum levels of HIF-1αand ACTH.

关 键 词：板蓝根颗粒 鼻咽癌 急性放射性口腔黏膜炎 缺氧诱导因子-1Α 促肾上腺皮质激素 

分 类 号：R273[医药卫生—中西医结合]