粪钙卫蛋白检测在婴儿过敏性肠炎鉴别诊断中的应用价值  

Application Value of Fecal Calprotectin Detection in Differential Diagnosis of Allergic Enteritis in Infants

作　　者：廖晓卿 谢美燕 何琳 LIAO Xiaoqing;XIE Meiyan;HE Lin(Department of Gastroenterology,Ganzhou Maternal and Child Health Hospital,Ganzhou 341000,China;不详)

机构地区：[1]赣州市妇幼保健院儿童消化内科,江西赣州341000 [2]赣州市妇幼保健院急诊科,江西赣州341000

出　　处：《中国医学创新》2024年第27期135-138,共4页Medical Innovation of China

基　　金：赣州市科技计划项目(2021年度)(C72021ZSF291)。

摘　　要：目的:探讨粪钙卫蛋白检测在婴儿过敏性肠炎鉴别诊断中的应用价值。方法:选取2019年6月—2021年6月于赣州市妇幼保健院治疗的74例过敏性肠炎患儿作为观察组,同时选取同期于本院治疗的70例细菌性肠炎患儿作为对照组。留取两组粪便标本,采用双抗夹心法检测粪钙卫蛋白水平;采集两组外周静脉血,离心取上清液,采用全自动血液分析仪检测白细胞计数(WBC)水平,采用特定蛋白分析仪检测C反应蛋白(CRP)水平。比较两组粪钙卫蛋白、CRP及WBC水平,绘制受试者操作特征(ROC)曲线,分析粪钙卫蛋白、CRP及WBC诊断过敏性肠炎的曲线下面积(AUC)、敏感度及特异度。结果:观察组粪钙卫蛋白、CRP及WBC水平均低于对照组,差异均有统计学意义(P<0.05);ROC曲线结果显示,粪钙卫蛋白诊断过敏性肠炎的AUC、敏感度均高于CRP及WBC单独诊断。结论:过敏性肠炎患儿粪钙卫蛋白、CRP及WBC水平较细菌性肠炎患儿低,采用粪钙卫蛋白检测鉴别诊断婴儿过敏性肠炎价值较高,可有效预测婴儿过敏性肠炎的发生,为临床尽早干预提供参考。Objective:To investigate the application value of fecal calprotectin detection in differential diagnosis of allergic enteritis in infants.Method:A total of 74 infants with allergic enteritis who were treated in Ganzhou Maternal and Child Health Hospital from June 2019 to June 2021 were selected as the observation group,and 70 infants with bacterial enteritis who were treated in our hospital during the same period were selected as the control group.Fecal samples of two groups were collected and the level of fecal calprotectin was detected by double anti-sandwich method.Peripheral venous blood of the two groups was collected,and supernatant was obtained by centrifugation.White blood cell count(WBC)level was detected by automatic blood analyzer,and C reactive protein(CRP)level was detected by specific protein analyzer.The levels of fecal calprotectin,CRP and WBC were compared between the two groups,receiver operating characteristic(ROC)curves were drawn,and the area under the curve(AUC),sensitivity and specificity of fecal calprotectin,CRP and WBC in the diagnosis of allergic enteritis were analyzed.Result:The levels of fecal calprotectin,CRP and WBC in observation group were lower than those in control group,the differences were statistically significant(P<0.05).ROC curve analysis showed that the AUC,sensitivity of fecal calprotectin in the diagnosis of allergic enteritis were higher than those of CRP and WBC diagnosis alone.Conclusion:The levels of fecal calprotectin,CRP and WBC in infants with allergic enteritis are lower than those in infants with bacterial enteritis.The use of fecal calprotectin detection in the differential diagnosis of allergic enteritis in infants is of high value,which can effectively predict the occurrence of allergic enteritis in infants,and provide references for early clinical intervention.

关 键 词：婴儿过敏性肠炎 细菌性肠炎 粪钙卫蛋白 诊断效能 

分 类 号：R725.7[医药卫生—儿科]