甘油三酯-葡萄糖指数与直接PCI的非糖尿病ST段抬高型心肌梗死患者院内心源性休克的相关性分析  

Correlation between triglyceride-glucose index and in-hospital cardiogenic shock in non-diabetic patients with ST-segment elevation myocardial infarction undergoing direct PCI

作　　者：王晓飞 仲程豪 钱四辈 杨玲[1] 毛郁 WANG Xiaofei;ZHONG Chenghao;QIAN Sibei;YANG Ling;MAO Yu(Cardiovascular Medicine Department,the First People's Hospital of Changzhou/the Third Affiliated Hospital of Soochow University,Changzhou 213000,China)

机构地区：[1]常州市第一人民医院/苏州大学附属第三医院心血管内科,江苏常州213000

出　　处：《临床医学研究与实践》2024年第27期14-17,190,共5页Clinical Research and Practice

基　　金：2022年度常州市第四周期医学重点学科(No.CZXK202202)。

摘　　要：目的分析甘油三酯-葡萄糖(TyG)指数与直接经皮冠状动脉介入治疗(PCI)的非糖尿病ST段抬高型心肌梗死(STEMI)患者院内心源性休克(CS)的相关性。方法回顾性分析2017年1月至2022年7月在常州市第一人民医院接受直接PCI治疗的839例非糖尿病STEMI患者的临床资料,根据TyG指数三分位数将其分为Q1组、Q2组和Q3组,分析直接PCI治疗的非糖尿病STEMI患者发生CS的影响因素。结果根据TyG指数三分位数,Q1组纳入280例、Q2组纳入279例、Q3组纳入280例。Spearman相关性分析结果显示,TyG指数与CS的发生呈正相关(P<0.05)。多因素Logistic回归分析结果显示,TyG指数、中性粒细胞比例、血小板计数、肌酐、左室射血分数(LVEF)是直接PCI治疗的非糖尿病STEMI患者发生CS的独立影响因素(P<0.05)。受试者工作特征(ROC)曲线显示,TyG指数预测CS的曲线下面积(AUC)为0.614,灵敏度为52.5%,特异度为67.6%。结论直接PCI治疗的非糖尿病STEMI患者高TyG指数与院内CS相关。Objective To analyze the correlation between triglyceride-glucose(TyG)index and in-hospital cardiogenic shock(CS)in non-diabetic patients with ST-segment elevation myocardial infarction(STEMI)undergoing direct percutaneous coronary intervention(PCI).Methods The clinical data of 839 non-diabetic STEMI patients who received direct PCI in the First People's Hospital of Changzhou from January 2017 to July 2022 were retrospectively analyzed.According to the tertile of TyG index,the patients were divided into Q1 group,Q2 group and Q3 group.The influencing factors of CS in non-diabetic STEMI patients treated with direct PCI were analyzed.Results According to the tertile of TyG index,280 cases were included in the Q1 group,279 cases in the Q2 group and 280 cases in the Q3 group.Spearman correlation analysis showed that TyG index was positively correlated with the occurrence of CS(P<0.05).Multivariate Logistic regression analysis showed that TyG index,neutrophil ratio,platelet count,creatinine and left ventricular ejection fraction(LVEF)were independent influencing factors of CS in non-diabetic STEMI patients treated with direct PCI(P<0.05).The receiver operating characteristic(ROC)curve showed that the areas under curve(AUC)of TyG index for predicting CS was 0.614,the sensitivity was 52.5%,and the specificity was 67.6%.Conclusion High TyG index is associated with in-hospital CS in non-diabetic STEMI patients undergoing direct PCI.

关 键 词：甘油三酯-葡萄糖指数 ST段抬高型心肌梗死 心源性休克 

分 类 号：R542.22[医药卫生—心血管疾病]