冻干重组人脑利钠肽联合布美他尼治疗急性左心衰竭患者的效果及对临床症状、心功能的影响  

Effect of lyophilized recombinant human brain natriuretic peptide combined with bumetanide in the treatment of patients with acute left heart failure and its influences on clinical symptoms and cardiac function

作　　者：王芬 雷雪婷 WANG Fen;LEI Xueting(Cardiology Department,Xi'an Tangcheng Hospital,Xi'an 710000;Cardiovascular Internal Medicine Department,the People's Hospital of Shanyang County,Shangluo 726400,China)

机构地区：[1]西安唐城医院心内科,陕西西安710000 [2]山阳县人民医院心血管内科,陕西商洛726400

出　　处：《临床医学研究与实践》2024年第27期54-57,共4页Clinical Research and Practice

摘　　要：目的探讨冻干重组人脑利钠肽联合布美他尼治疗急性左心衰竭患者的效果及对临床症状、心功能的影响。方法选取2022年9月至2023年9月收治的100例急性左心衰竭患者作为研究对象,经随机数字表法将其分为对照组和观察组,各50例。两组患者均给予对症处理,在此基础上,对照组给予布美他尼治疗,观察组给予冻干重组人脑利钠肽联合布美他尼治疗。比较两组的治疗效果。结果观察组的治疗总有效率显著高于对照组(P<0.05)。观察组的呼吸困难缓解时间短于对照组(P<0.05);治疗后,观察组的呼吸频率、血浆N末端前脑钠肽水平均低于对照组(P<0.05)。治疗后,观察组的左心室舒张末期内径、左心室收缩末期内径均小于对照组,左心室射血分数高于对照组(P<0.05)。治疗后,观察组的丙二醛(MDA)水平及心率、收缩压与舒张压均低于对照组,超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)水平均高于对照组(P<0.05)。结论冻干重组人脑利钠肽联合布美他尼治疗急性左心衰竭患者的效果显著,可缓解临床症状,促进心功能改善,下调血浆N末端前脑钠肽水平。Objective To investigate the effect of lyophilized recombinant human brain natriuretic peptide combined with bumetanide in the treatment of patients with acute left heart failure and its influences on clinical symptoms and cardiac function.Methods A total of 100 patients with acute left heart failure from September 2022 to September 2023 were selected as the research objects and divided into control group and observation group by random number table method,with 50 cases in each group.Both groups were given symptomatic treatment.On this basis,the control group was treated with bumetanide,and the observation group was treated with lyophilized recombinant human brain natriuretic peptide combined with bumetanide.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was significantly higher than that in the control group(P<0.05).The relief time of dyspnea in the observation group was shorter than that in the control group(P<0.05);after treatment,the respiratory rate and plasma N-terminal pro-brain natriuretic peptide level in the observation group were lower than those in the control group(P<0.05).After treatment,the left ventricular end-diastolic diameter and left ventricular end-systolic diameter in the observation group were less than those in the control group,and the left ventricular ejection fraction was higher than that in the control group(P<0.05).After treatment,the malondialdehyde(MDA)level,heart rate,systolic blood pressure and diastolic blood pressure in the observation group were lower than those in the control group,and the levels of superoxide dismutase(SOD)and glutathione peroxidase(GSH-Px)were higher than those in the control group(P<0.05).Conclusion The lyophilized recombinant human brain natriuretic peptide combined with bumetanide in the treatment of patients with acute left heart failure has a significant effect,which can relieve clinical symptoms,promote the improvement of cardiac function,and down-regulate the level of plas

关 键 词：冻干重组人脑利钠肽 布美他尼 急性左心衰竭 心功能 

分 类 号：R541.6[医药卫生—心血管疾病]