升陷汤联合雾化吸入治疗大气下陷证慢性阻塞性肺疾病急性加重期临床研究  

Clinical Study on Shengxian Decoction Combined with Nebulization Inhalation for Acute Exacerbation of Chronic Obstructive Pulmonary Disease with Sinking of Pectoral Qi Syndrome

作　　者：陈逍 林翔 CHEN Xiao;LIN Xiang(Department of Chinese Medicine,Zhejiang Medical&Health Group Changxing Hospital,Changxing Zhejiang 313117,China)

机构地区：[1]浙江省医疗健康集团长兴医院中医科,浙江长兴313117

出　　处：《新中医》2024年第18期28-33,共6页New Chinese Medicine

摘　　要：目的:观察升陷汤联合雾化吸入治疗大气下陷证慢性阻塞性肺疾病急性加重期(AECOPD)的临床疗效。方法:按随机数字表法将120例大气下陷证AECOPD患者分为观察组与对照组各60例。对照组给予硫酸沙丁胺醇雾化吸入治疗,观察组在对照组基础上联合升陷汤治疗,均连续治疗2周后评估2组临床疗效、中医证候评分,以及治疗前后肺功能[第1秒用力呼气容积(FEV1)、用力肺活量(FVC)、FEV1占预计值的百分比(FEV1%)、FEV1/FVC]、炎症因子[降钙素原(PCT)、C-反应蛋白(CRP)]及氧化应激指标[丙二醛(MDA)、超氧化物歧化酶(SOD)]水平变化。结果:观察组总有效率为95.00%,对照组为81.67%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组中医证候评分均较治疗前降低(P<0.05),且观察组评分低于对照组(P<0.05)。治疗后,2组FEV1、FVC、FEV1%、FEV1/FVC水平均较治疗前升高(P<0.05),且观察组上述各项指标水平均高于对照组(P<0.05)。治疗后,2组血清PCT、CRP水平均较治疗前降低(P<0.05),且观察组上述2项指标水平均低于对照组(P<0.05)。治疗后,2组MDA水平均较治疗前降低(P<0.05),且观察组MDA水平低于对照组(P<0.05);2组SOD水平均较治疗前升高(P<0.05),且观察组SOD水平高于对照组(P<0.05)。结论:升陷汤联合雾化吸入治疗大气下陷证AECOPD效果确切,对缓解患者中医证候,改善肺功能,减轻机体炎症反应及调节氧化应激反应均具有积极作用。Objective:To observe the clinical effect of Shengxian Decoction combined with nebulization inhalation for acute exacerbation of chronic obstructive pulmonary disease(AECOPD)with sinking of pectoral qi syndrome.Methods:A total of 120 cases of patients with AECOPD with sinking of pectoral qi syndrome were divided into the observation group and the control group by random number table method,with 60 cases in each group.The control group was treated with nebulized inhalation of Salbutamol Sulfate,and the observation group was additionally treated with Shengxian Decoction based on the control group.After two weeks of continuous treatment,clinical effects and traditional Chinese medicine(TCM)syndrome scores were evaluated;the changes in lung function[forced expiratory volume in one second(FEV1),forced vital capacity(FVC),the percentage of FEV1 to the expected value(FEV1%),and FEV1/FVC],inflammatory factors[procalcitonin(PCT)and C-reactive protein(CRP)],and oxidative stress indicators[malondialdehyde(MDA)and superoxide dismutase(SOD)]levels before and after treatment were observed.Results:The total effective rate was 95.00%in the observation group and 81.67%in the control group,and the difference between the two groups was significant(P<0.05).After treatment,the TCM syndrome scores in the two groups were reduced when compared with those before treatment(P<0.05),and the scores in the observation group were lower than those in the control group(P<0.05).After treatment,FEV1,FVC,FEV1%,and FEV1/FVC in the two groups were increaed when compared with those before treatment(P<0.05),and the above indicators in the observation group were higher than those in the control group(P<0.05).After treatment,the levels of PCT and CRP in serum in the two groups were decreased when compared with those before treatment(P<0.05),and the above two indicators in the observation group were lower than those in the control group(P<0.05).After treatment,the levels of MDA in the two groups were declined when compared with those before treatment(P<0.0

关 键 词：慢性阻塞性肺疾病急性加重期 大气下陷证 升陷汤 雾化吸入 肺功能 炎症反应 氧化应激反应 

分 类 号：R563[医药卫生—呼吸系统]