补气增液汤加减联合针刺治疗气阴两虚型慢传输型便秘临床研究  

Clinical Study on Modified Buqi Zengye Decoction Combined with Acupuncture for Slow Transit Constipation of Dual Deficiency of Qi and Yin Type

作　　者：周建锋 唐苏琳 ZHOU Jianfeng;TANG Sulin(Yuyao People's Hospital,Yuyao Zhejiang 315400,China)

机构地区：[1]余姚市人民医院,浙江余姚315400

出　　处：《新中医》2024年第18期66-71,共6页New Chinese Medicine

摘　　要：目的:观察补气增液汤加减联合针刺治疗气阴两虚型慢传输型便秘(STC)的临床疗效。方法:选取90例气阴两虚型STC患者,按随机数字表法分为试验组、对照1组及对照2组,每组30例。对照1组剔除2例,对照2组剔除1例,最终纳入试验组30例、对照1组28例、对照2组29例。对照1组给予补气增液汤加减治疗,对照2组给予针刺治疗,试验组给予补气增液汤加减联合针刺治疗,3组均治疗30 d。比较3组临床疗效、便秘症状积分、标记物排出结果及胃肠激素[P物质(SP)及血管活性肠肽(VIP)]水平,评估治疗安全性。结果:治疗后,试验组总有效率96.67%,高于对照1组75.00%、对照2组68.97%(P<0.05)。3组粪便性状,腹胀,排便困难,排便时间,下坠、不尽、胀感,排便频率积分均较治疗前下降(P<0.05),试验组上述6项便秘症状积分均低于对照1组、对照2组(P<0.05)。3组运输异常数均较治疗前减少(P<0.05),试验组运输异常数少于对照1组、对照2组(P<0.05);3组48 h标记物排出数、72 h标记物排出数、72 h标记物排出率均较治疗前提高(P<0.05),试验组上述3项指标值均高于对照1组、对照2组(P<0.05)。3组血清SP水平均较治疗前升高(P<0.05),血清VIP水平均较治疗前下降(P<0.05);试验组血清SP水平均高于对照1组、对照2组(P<0.05),血清VIP水平均低于对照1组、对照2组(P<0.05)。对照1组、对照2组上述各项指标治疗后比较,差异均无统计学意义(P>0.05)。治疗期间,3组均未出现不良反应。结论:补气增液汤加减联合针刺治疗气阴两虚型STC疗效确切,可有效改善临床症状,提高结肠传输功能,调节胃肠激素水平,安全性高。Objective:To observe the clinical effect of the combination use of modified Buqi Zengye Decoction and acupuncture on slow transit constipation(STC)of dual deficiency of qi and yin type.Methods:A total of 90 cases of STC patients of dual deficiency of qi and yin type were selected and assigned to the trial group,the control group 1 and the control group 2 according to the random number table method,with 30 cases in each group.Two cases were culled in the control group 1 and one case was culled in the control group 2,and finally 30,28 and 29 cases were included in the trial group,the control group 1 and the control group 2 respectively.The control group 1 was treated with modified Buqi Zengye Decoction,the control group 2 was treated with acupuncture and the trial group was combination use of modified Buqi Zengye Decoction and acupuncture.The three groups were treated for 30 days.The clinical effects,scores of constipation-related symptoms,results of discharged marker,and levels of gastrointestinal hormones[substance P(SP)and vasoactive intestinal peptide(VIP)]were compared between the three groups;the treatment safety was evaluated.Results:After treatment,the total effective rate was 96.67%in the trial group,higher than that of 75.00%in the control group 1 and 68.97%in the control group 2(P<0.05).The scores of stools characters,abdominal distention,difficulty in defecation,defecation time,straining,endless defecation and defecation frequency in the three groups were down-regulated when compared with those before treatment(P<0.05),and the above six scores in the trial group were lower than those in the control group 1 and the control group 2(P<0.05).The number of transit abnormalities in the three groups were reduced when compared with those before treatment(P<0.05),and the number of transit abnormalities in the trial group was less than that in the control group 1 and the control group 2(P<0.05);the number of discharged 48 h marker and 72 h marker,and the rate of discharged 72 h marker in the three groups were ele

关 键 词：慢传输型便秘 气阴两虚型 补气增液汤 针刺 结肠传输功能 胃肠激素 

分 类 号：R256.35[医药卫生—中医内科学]