地龙冬花汤加减治疗儿童哮喘急性发作期合并肺炎支原体感染临床研究  

Clinical Study on Modified Dilong Donghua Decoction for Children with Acute Attack of Asthma Complicated with Mycoplasma Pneumoniae Infection

作　　者：赵佳烨 曾莺 ZHAO Jiaye;ZENG Ying(Foshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Chinese Medicine,Foshan Guangdong 528000,China)

机构地区：[1]广州中医药大学附属佛山中医院,广东佛山528000

出　　处：《新中医》2024年第18期98-102,共5页New Chinese Medicine

基　　金：广东省第三批名中医师承项目(粤中医办函[2018]5号)。

摘　　要：目的:观察地龙冬花汤加减治疗痰浊郁肺型儿童哮喘急性发作期合并肺炎支原体(MP)感染的临床疗效。方法:选取50例痰浊郁肺型哮喘急性发作期合并MP感染患儿,采用随机数字表法分为对照组和治疗组,每组25例。对照组给予阿奇霉素干混悬剂与布地奈德福莫特罗粉吸入剂治疗,治疗组在对照组基础上加用地龙冬花汤加减治疗。2组疗程均为8周。比较2组临床疗效、中医证候积分、呼气峰流速占预计值的百分比(PEF%pred)及第1秒用力呼气容积占预计值的百分比(FEV1%pred)。结果:治疗8周后,治疗组总有效率96.00%,与对照组88.00%比较,差异无统计学意义(P>0.05)。2组中医证候积分均较治疗前降低,治疗组中医证候积分低于对照组,差异均有统计学意义(P<0.05)。2组PEF%pred、FEV1%pred均较治疗前升高,治疗组PEF%pred、FEV1%pred均高于对照组,差异均有统计学意义(P<0.05)。结论:地龙冬花汤加减能够改善痰浊郁肺型哮喘急性发作期合并MP感染患儿的临床症状、体征和肺功能,有效控制哮喘发作。Objective:To observe the clinical effect of modified Dilong Donghua Decoction on children with acute attack of asthma complicated with mycoplasma pneumoniae(MP)infection of phlegm turbidity obstructing the lung type.Methods:A total of 50 cases of children with acute attack of asthma complicated with MP infection of phlegm turbidity obstructing the lung type were selected and divided into the control group and the treatment group by random number table method,with 25 cases in each group.The control group was treated with Azithromycin Dry Suspension and Budesonide Formoterol Powder Inhaler,and the treatment group was additionally treated with modified Dilong Donghua Decoction based on the treatment of the control group.Both groups were treated for eight weeks.The clinical effects,traditional Chinese medicine(TCM)syndrome scores,peak expiratory flow rate in the predicted value(PEF%pred)and forced expiratory volume in the first second in the predicted value(FEV1%pred)were compared between the two groups.Results:After eight weeks of treatment,the total effective rate was 96.00%in the treatment group and 88.00%in the control group,there being no significant difference between the two groups(P>0.05).The TCM syndrome scores in the two groups were decreased when compared with those before treatment,and the TCM syndrome score in the treatment group was lower than that in the control group,differences being significant(P<0.05).The PEF%pred and FEV1%pred in the two groups were elevated when compared with those before treatment,and PEF%pred and FEV1%pred in the treatment group were higher than those in the control group,differences being significant(P<0.05).Conclusion:Modified Dilong Donghua Decoction can improve the clinical symptoms,signs and lung function of children with acute attack of asthma complicated with MP infection of phlegm turbidity obstructing the lung type,and effectively control an asthma attack.

关 键 词：哮喘 急性发作期 肺炎支原体 儿童 痰浊郁肺型 地龙冬花汤 肺功能 

分 类 号：R725.6[医药卫生—儿科]