基于络病理论探讨“肾虚络瘀”病机观在老年慢性肾脏病中与细胞自噬不足相关性  

Relationship Between Pathogenesis of"Kidney Deficiency and Bloo d Stasis"and Autophagy Dysfunction in Elderly Patients with Chronic Kidney Disease Based on the Theory of Collateral Diseases

作　　者：曹芳[1] 温恪健 高磊平[1] 汪悦[2] CAO Fang;WEN Kejian;GAO leiping;WANG Yue(Changshu Hospital Affiliated of Nanjing University of Chinese Medicine,Jiangsu Changshu 215500,China;The Hospital Affiliated of Nanjing University of Chinese Medicine,Jiangsu Nanjing 210029,China)

机构地区：[1]南京中医药大学常熟附属医院,江苏常熟215500 [2]南京中医药大学附属医院,江苏南京210029

出　　处：《中医药临床杂志》2024年第9期1647-1650,共4页Clinical Journal of Traditional Chinese Medicine

基　　金：常熟市科技发展计划项目(CY202313)。

摘　　要：以中医络病理论为指导,结合现代临床与基础研究,提出老年慢性肾脏病(chronic kidney disease,CKD)主要病机为“肾虚络瘀”,年老肾虚气化不足,致湿浊、血瘀阻滞肾络,其病理过程与衰老过程中细胞自噬不足、病理产物清除减少损伤肾脏具有相同的病机演变格局,补虚通络法通过调控细胞自噬发挥肾脏保护作用,延缓老年CKD进展。通过探讨老年CKD“肾虚络瘀”的科学内涵,进一步从分子水平解释老年CKD的作用机制及靶点,为该病的中医治疗及其机制研究提供新的研究思路和科学依据。Drawing upon the traditional Chinese medicine(TCM)theory of collateral diseases,this study integrates contemporary clinical and basic research findings to posit that the primary pathological mechanism underlying chronic kidney disease(CKD)in the elderly is"kidney deficiency and collateral stasis."As individuals age,kidney qi wanes,compromising its transformative functions,leading to the accumulation of dampness-turbidity and blood stasis that obstructs the kidney collaterals.This pathological cascade mirrors the reduced autophagy and inefficient clearance of pathological products seen during the aging process,both ultimately contributing to kidney damage.The therapeutic strategy of tonifying kidney essence and dredging the collaterals aims to protect the kidneys by modulating autophagy,thereby slowing the progression of CKD in the elderly.By delving into the scientific essence of"kidney deficiency and collateral stasis"in elderly CKD,this study offers fresh perspectives and robust scientific foundations for the TCM treatment and underlying mechanisms of this condition.

关 键 词：络病理论 肾虚络瘀 老年慢性肾脏病 细胞自噬 

分 类 号：R692[医药卫生—泌尿科学]