从“湿热”辨治特发性肺纤维化探析  

Differentiation and Treatment of Idiopathic Pulmonary Fibrosis from"Dampness and Heat"

作　　者：王昊[1] 宋莉莎 周佩夏 赵国静 孙英 宋欢 胡海波 陆学超 WANG Hao;SONG Lisha;ZHOU Peixia;ZHAO Guojing;SUN Ying;SONG Huan;HU Haibo;LUXuechao(Shandong University of Traditional Chinese Medicine,Shandong Ji’nan 250013,China;Qingdao Traditional Chinese Medicine Hospital,Shandong Qingdao 250013,China)

机构地区：[1]山东中医药大学,山东济南250013 [2]青岛市中医医院,山东青岛266033

出　　处：《中医药临床杂志》2024年第9期1710-1714,共5页Clinical Journal of Traditional Chinese Medicine

基　　金：青岛市中医药科技项目(NO.2022-zyym06);山东省中医药科技项目(NO.2020Q074)。

摘　　要：特发性肺纤维化(Idiopathic Pulmonary Fibrosis,IPF)是一种病因尚不明确、渐进性的慢性炎症性间质性肺疾病,是世界性疑难疾病之一,其死亡率高,目前世界范围内仅有尼达尼布、吡非尼酮被指南列入为有条件可使用的药物,但其副作用大,因此寻找安全、高效、经济的IPF治疗药物迫在眉睫。中医药因其多靶点、多环节、多层次,多通路的独特优势,近年来,中医药治疗IPF在理论和临床方面均取得了一定进展。文章以“湿热”为理论依据,从病因病机、湿热蕴肺之来源、致瘀、致虚、致毒、临床治疗方法及经验等方面对近年来的相关研究进行综合概述,以期提供新的辨治思路,提高临床疗效。Idiopathic pulmonary fibrosis(IPF)is a progressive chronic inflammatory interstitial lung disease of unknown etiology.IPF is one of the most difficult diseases in the world with high mortality.At present,there are only Nidanib and Pirfenidone in the world which can be used conditionally.However,the side effects of Nidanib and Pirfenidone are great.Therefore,it is urgent to find a safe,efficient and economical drug to treat IPF.Because of its unique advantages of multi-target,multi-link,multi-level and multi-pathway,in recent years,the treatment of IPF with TCM has made certain progress in theory and clinical aspects.The article is based on the theory of"damp heat"As the theoretical basis,this article summarizes the related research in recent years from the aspects of etiology and pathogenesis,the source of damp-heat accumulating in the lung,blood stasis,deficiency and toxicity,clinical treatment methods and experience,in order to provide new ideas for treatment and improve clinical efficacy.

关 键 词：湿热 辨证 论治 特发性肺纤维化 

分 类 号：R563[医药卫生—呼吸系统]