运动疗法联合九味固金胶囊对慢性阻塞性肺疾病稳定期肺肾两虚型患者肺功能的影响  

Effect of Exercise Therapy Combined with Jiuwei Gujin Capsule on Pulmonary Function of COPD Patents with Lung-kidney Concurrent Deficiency in Stable Stage

作　　者：关炜[1] 刘欢 康昱 成嘉欣 GUAN Wei;LIU Huan;KANG Yu;CHENG Jiaxin(Shanxi Provincial Hospital of Traditional Chinese Medicine Shanxi Taiyuan 030012,China;Shanxi University of Traditional Chinese Medicine Shanxi Jinzhong 030619,China)

机构地区：[1]山西省中医院,山西太原030012 [2]山西中医药大学,山西晋中030619

出　　处：《中医药临床杂志》2024年第9期1777-1781,共5页Clinical Journal of Traditional Chinese Medicine

基　　金：山西省中医院中医临床医学研究中心专项经费支持(LCYJZX202116);杜秀娟全国名老中医药专家传承工作室(1169-06)。

摘　　要：目的:研究运动疗法联合九味固金胶囊对慢性阻塞性肺疾病(COPD)稳定期肺肾两虚型患者肺功能的影响。方法:将山西省中医院符合标准的114例COPD稳定期肺肾两虚型患者按随机数字表法分为A组:运动训练+九味固金胶囊组(n=27)、B组:九味固金胶囊组(n=29)、C组:运动训练组(n=28)、D组:基础治疗组(n=30)。A、B、C组在D组基础上分别加用运动训练联合九味固金胶囊、九味固金胶囊、运动训练,治疗周期为1月,观察各组肺功能指标(FEV1/FVC%、FEV1%)、动脉血气指标(PaO_(2)、PaCO_(2))。结果:与治疗前相比,4组肺功能(FEV1/FVC%、FEV1%)、PaO_(2)、A组PaCO_(2)均有改善,差异具有统计学意义(P<0.01),B组、C组、D组PaCO_(2)治疗前后无明显差异(P>0.05)。与D组相比,治疗后A组肺功能(FEV1/FVC%、FEV1%)、PaO_(2)显著改善,差异具有统计学意义(P<0.05)。治疗后B组与C组相比肺功能(FEV1/FVC%、FEV1%)无明显差异(P>0.05),而PaO_(2)有显著差异,C组强于B组。九味固金胶囊和运动训练对于改善改善肺功能(FEV1/FVC%、FEV1%),二者交互作用不显著(P>0.05),合用不如单用运动训练,对于改善PaO_(2),二者交互作用显著(P<0.05),联合使用效果最好。结论:运动疗法联合九味固金胶囊可以较好改善COPD稳定期肺肾两虚型患者的肺功能。Objective:To study the effect of exercise therapy combined with Jiuwei Gujin capsule on lung function in patients with lung and kidney deficiency in stable COPD.Methods:A total of 114 patients with lung and kidney deficiency in stable COPD who met the criteria in Shanxi Provincial Hospital of Traditional Chinese Medicine were randomly divided into group A:exercise training+Jiuwei Gujin capsule group(n=27),group B:Jiuwei Gujin capsule group(n=29),group C:exercise training group(n=28),and group D:basic treatment group(n=30).Groups A,B,and C were treated with exercise training combined with Jiuwei Gujin capsule,Jiuwei Gujin capsule,and exercise training,respectively,on the basis of group D.The treatment cycle was 1 month,and the lung function indexes(FEV1/FVC%,FEV1%)and arterial blood gas indexes(PaO_(2),PaCO_(2))were observed in each group.Results:Compared with before treatment,the lung function(FEV1/FVC%,FEV1%),PaO_(2) of the four groups and PaCO_(2) of group A were improved,and the difference was statistically significant(P<0.01).There was no significant difference in PaCO_(2) before and after treatment in groups B,C and D(P>0.05).Compared with group D,the lung function(FEV1/FVC%,FEV1%)and PaO_(2) of group A were significantly improved after treatment,and the difference was statistically significant(P<0.05).After treatment,there was no significant difference in lung function(FEV1/FVC%,FEV1%)between group B and group C(P>0.05),but there was a significant difference in PaO_(2),and group C was stronger than group B.Jiuwei Gujin capsule and exercise training improved lung function(FEV1/FVC%,FEV1%),and the interaction between the two was not significant(P>0.05).The combined use was not as good as exercise training alone.For improving PaO_(2),the interaction between the two was significant(P<0.05),and the combined use had the best effect.Conclusion:Exercise therapy combined with Jiuwei Gujin capsule can effectively improve the lung function of patients with lung and kidney deficiency in the stable stage of COPD.

关 键 词：运动疗法 九味固金胶囊 慢性阻塞性肺疾病 肺肾两虚 肺功能 血气分析 

分 类 号：R256.14[医药卫生—中医内科学]