补益活血类中药调控血管内皮生长因子防治骨质疏松症研究概况  

Research Progress on the Regulation of Vascular Endothelial Growth Factor by Tonifying and Promoting Blood Circulation Traditional Chinese Medicine in the Prevention and Treatment of Osteoporosis

作　　者：郭宏 俞鹏飞[1] 李稳超 李亚浩 李宇卫[1] 朱广晔 李红卫[1] GUO Hong;YU Pengfei;LI Wenchao;LI Yahao;LI Yuwei;ZHU Guangye;LI Hongwei(Suzhou Hospital Affiliated of Nanjing University of Traditional Chinese Medicine Jiangsu Suzhou 215300,China;Nanjing University of Traditional Chinese Medicine Jiangsu Nanjing 210000,China)

机构地区：[1]南京中医药大学附属苏州医院,江苏苏州215300 [2]南京中医药大学,江苏南京210000

出　　处：《中医药临床杂志》2024年第9期1821-1826,共6页Clinical Journal of Traditional Chinese Medicine

基　　金：江苏省科教能力提升工程:江苏省医学重点学科,实验室建设单位(苏卫科教〔2022〕17号);苏州市卫生健康委员会科技项目(NO.LCZX202113);江苏省老年健康科研项目(NO.LKM2022055)。

摘　　要：骨质疏松症(osteoporsis,OP)是老年人死亡的常见、重要原因之一,血管内皮生长因子(Vascular endothelial growth factor,VEGF)是最有效的诱导血管生成的高度特异性生长因子。可以偶联血管与骨生成,促进骨组织内血管再生,诱导成骨增强。研究显示中药可以调控VEGF从而治疗椎间盘退变。中药是中国治疗OP的重要手段之一,具有多靶点、多途径、整体性的特点,可以弥补西药单一对症治疗的不足,具有广阔的应用前景。文章综述各类经典中药在骨质疏松发生发展过程中对VEGF水平及其介导通路的调节作用,为补益活血类中药的临床应用及基础研究提供参考,为中医药防治OP在理论与机制研究上提供新的思路。文章综述在骨质疏松发生和发展过程中,各种经典中药对VEGF水平及其介导通路的调节作用,在理论和机制研究上为中医药防治OP提供新思路,以供临床应用和补益活血中药的基础研究。Osteoporosis(OP)is one of the common and important causes of death in the elderly.Vascular endothelial growth factor(VEGF)is the most effective and highly specific growth factor that induces angiogenesis.It can couple angiogenesis and bone formation,promote blood vessel regeneration in bone tissue,and induce osteogenesis.Studies have shown that Chinese medicine can regulate VEGF to treat intervertebral disc degeneration.Chinese medicine is one of the important means of treating OP in China.It has the characteristics of multi-target,multi-pathway,and holistic.It can make up for the shortcomings of single symptomatic treatment of Western medicine and has broad application prospects.This article reviews the regulatory effects of various classic Chinese medicines on VEGF levels and their mediated pathways in the occurrence and development of osteoporosis,providing a reference for the clinical application and basic research of Chinese medicines for invigorating blood circulation,and providing new ideas for the theoretical and mechanism research of Chinese medicine in the prevention and treatment of OP.This article reviews the regulatory effects of various classic Chinese medicines on VEGF levels and their mediated pathways during the occurrence and development of osteoporosis,providing new ideas for the prevention and treatment of OP with traditional Chinese medicine in terms of theory and mechanism research,and providing clinical application and basic research on tonic and blood-activating Chinese medicines.

关 键 词：血管内皮生长因子 骨质疏松 中药 

分 类 号：R274.9[医药卫生—中西医结合]