Gyroid结构钛仿生骨支架修复下颌骨节段性缺损的生物力学性能  

Biomechanical properties of Gyroid structured titanium bionic bone scaffolds for repairing segmental mandibular defects

作　　者：姜至秀 季俣辰 刘丹瑜 曹怡琳 姜婷婷 宋颐函[1,2,3] 王磊 王心彧 Jiang Zhixiu;Ji Yuchen;Liu Danyu;Cao Yilin;Jiang Tingting;Song Yihan;Wang Lei;Wang Xinyu(Key Laboratory of Biomedical Materials and Clinical Application in Heilongjiang Province,Jiamusi 154002,Heilongjiang Province,China;Experimental Center for Stomatological Engineering,Jiamusi University,Jiamusi 154002,Heilongjiang Province,China;School of Stomatology,Jiamusi University,Jiamusi 154002,Heilongjiang Province,China)

机构地区：[1]黑龙江省生物医学材料及应用重点实验室,黑龙江省佳木斯市154002 [2]佳木斯大学口腔医学工程实验中心,黑龙江省佳木斯市154002 [3]佳木斯大学口腔医学院,黑龙江省佳木斯市154002

出　　处：《中国组织工程研究》2025年第22期4621-4628,共8页Chinese Journal of Tissue Engineering Research

基　　金：黑龙江省自然科学基金项目(LH2022H089),项目负责人:王心彧。

摘　　要：背景:三周期最小表面的多孔结构是最有前景的骨科生物结构之一,其中的Gyroid结构具有高比表面积、高渗透率、均曲率为零等特点。目的:通过有限元分析结合力学压缩实验测试,筛选出与下颌骨松质骨弹性模量范围相匹配的4 mm单胞Gyroid结构TC4仿生骨支架壁厚区间。方法:建立不同壁厚(0.1,0.2,0.3,0.4,0.5,0.6,0.7,0.8 mm)4 mm单胞Gyroid结构有限元模型,分析Gyroid结构的等效弹性模量,筛选出与下颌骨松质骨弹性模量范围相匹配的Gyroid结构壁厚区间,壁厚分别为0.2,0.3,0.4,0.5,0.6,0.7 mm。根据有限元分析筛选结果,以Ti6Al4V为原料,采用选择性激光熔融技术制备不同壁厚的3D打印Gyroid结构试件,进行大颗粒喷砂酸蚀处理,通过力学压缩实验测试试件的弹性模量与抗压强度。结果与结论:(1)有限元分析结果显示,随着壁厚的增加,Gyroid结构的等效弹性模量升高,其中壁厚为0.2-0.7 mm Gyroid结构的等效弹性模量在下颌骨松质骨弹性模量范围内(1.5-4.0 GPa),用于3D打印Gyroid结构试件;(2)力学压缩实验结果显示,随着壁厚的增加,Gyroid结构试件的弹性模量与抗压强度均升高,其中0.3-0.5 mm壁厚Gyroid结构试件的弹性模量在下颌骨松质骨弹性模量范围内,0.3-0.7 mm壁厚Gyroid结构试件的抗压强度符合下颌骨的力学性能;(3)结果显示0.3-0.5 mm壁厚Gyroid结构与下颌骨的弹性模量范围相适应。BACKGROUND:Porous structures based on triple periodic minimal surfaces are one of the most promising orthopedic biostructures,among which the structure is characterized by high specific surface area,high permeability,and zero mean curvature.OBJECTIVE:To screen the wall thickness interval of TC4 bionic bone scaffolds with 4 mm single-cell Gyroid structure matching the elastic modulus range of cancellous bone of the mandible through finite element analysis combined with mechanical compression test testing.METHODS:The finite element model of the 4 mm single-cell Gyroid structure with different wall thickths(0.1,0.2,0.3,0.4,0.5,0.6,0.7,and 0.8 mm)was established.The equivalent elastic modulus of the Gyroid structure was analyzed,and the wall thickness interval of the Gyroid structure matching the elastic modulus range of the maxillary resinous bone was selected with different wall thicknesses of 0.2,0.3,0.4,0.5,0.6,and 0.7 mm,respectively.According to finite element analysis screening results,the material selected was Ti6Al4V.Selective laser melting was used to prepare 3D printed Gyroid structure specimens.The surface treatment was carried out by large-grained sand blasting and acid etching.The elastic modulus and compressive strength of the specimen were tested by mechanical compression experiment.RESULTS AND CONCLUSION:(1)The finite element analysis results showed that the equivalent elastic modulus of the Gyroid structure increased with the increase of wall thickness,and the equivalent elastic modulus of the Gyroid structure with wall thickness of 0.2-0.7 mm was within the range of the elastic modulus of the spongy bone of the mandible(1.5-4.0 GPa),which was used for 3D printing of the Gyroid structure specimen.(2)The mechanical compression test results showed that the elastic modulus and compressive strength of the Gyroid structural specimen increased with the increase of wall thickness,and the elastic modulus of the Gyroid structural specimen with wall thickness of 0.3-0.5 mm was within the range of the elastic

关 键 词：节段性骨缺损 Gyroid结构 3D打印 选择性激光熔融 有限元 力学性能 

分 类 号：R459.9[医药卫生—治疗学] R318.08[医药卫生—临床医学] R782.4