自组装短肽水凝胶治疗肿瘤的作用  

Effects of self-assembling peptide hydrogels on tumor treatment

作　　者：贺欢欢 田诗佳 陈罗英 刘燕飞 He Huanhuan;Tian Shijia;Chen Luoying;Liu Yanfei(Key Laboratory of Cell Engineering,Affiliated Hospital of Zunyi Medical University,Zunyi 563000,Guizhou Province,China;Organizational Injury Repair and Regenerative Medicine Provincial and Departmental Collaborative Innovation Center,Zunyi Medical University,Zunyi 563000,Guizhou Province,China)

机构地区：[1]遵义医科大学附属医院细胞工程重点实验室,贵州省遵义市563000 [2]遵义医科大学组织损伤修复与再生医学省部共建协同创新中心,贵州省遵义市563000

出　　处：《中国组织工程研究》2025年第22期4795-4803,共9页Chinese Journal of Tissue Engineering Research

基　　金：贵州省科技厅基础研究项目(黔科合基础-ZK[2024]316),项目负责人:刘燕飞。

摘　　要：背景:自组装短肽水凝胶具有良好的生物相容性、可控的物理化学性质和释放性能,在组织工程、药物输送和生物传感等领域具有广泛的应用潜力。目的:总结近年来自组装短肽水凝胶在肿瘤治疗中的研究进展。方法:以“自组装短肽,水凝胶,缓释载体,抗肿瘤,肿瘤治疗;Self-assembling peptide,hydrogel,sustained release,antitumor,tumor therapy”为检索词,检索中国知网、PubMed、Elsevier ScienceDirect数据库2000-2024年发表的相关文献,最终纳入81篇文献进行综述。结果与结论:自组装短肽水凝胶作为一种新型的生物活性材料,可以作为缓释药物载体负载多种抗肿瘤药物、免疫抑制剂等,靶向肿瘤部位、诱导肿瘤细胞死亡、降低药物使用剂量、提高肿瘤部位药物蓄积量,从而降低毒副作用和多药耐药性的产生概率。此外,具有天然活性的抗肿瘤水凝胶能够不依赖于药物直接杀伤肿瘤细胞,单独使用能够最大限度避免抗肿瘤药物的毒副作用。BACKGROUND:Self-assembling peptide hydrogels exhibit excellent biocompatibility,controllable physicochemical properties,and release capabilities,offering extensive application potential in tissue engineering,drug delivery,and biosensing fields.OBJECTIVE:To summarize the research progress of self-assembling peptide hydrogel in cancer therapy in recent years.METHODS:Using the search terms“self-assembling peptides,hydrogel,sustained release,antitumor,tumor therapy”in Chinese and English,CNKI,PubMed,and Elsevier ScienceDirect databases were searched for relevant literature published from 2000 to 2024.Finally,81 articles were included in the review.RESULTS AND CONCLUSION:Self-assembling peptide hydrogels,as a novel biomaterial,can be used as a sustained-release drug carrier to load a variety of anti-tumor drugs,and immunosuppressants,targeting tumor sites,inducing tumor cell death,reducing drug dosage,and increasing drug accumulation in tumor sites,thereby reducing the probability of toxic side effects and multidrug resistance.Moreover,anti-tumor hydrogels with natural activity can directly kill tumor cells without relying on drugs,and can minimize the toxic side effects of anti-tumor drugs when used alone.

关 键 词：自组装短肽 水凝胶 药物缓释 抗肿瘤 组织工程 

分 类 号：R459.9[医药卫生—治疗学] R318.08[医药卫生—临床医学] R730.5