硒及硒纳米颗粒生物学机制与口腔常见疾病的关系  

Relationship between biological mechanism of selenium and selenium nanoparticles and common oral diseases

作　　者：彭璐瑶 顾瑜 Peng Luyao;Gu Yu(Zhuhai Campus of Zunyi Medical University,Zhuhai 519041,Guangdong Province,China;Guizhou Provincial University Key Laboratory of Oral Disease Research,Zunyi 563000,Guizhou Province,China)

机构地区：[1]遵义医科大学珠海校区,广东省珠海市519041 [2]贵州省高等学校口腔疾病研究特色重点实验室,贵州省遵义市563000

出　　处：《中国组织工程研究》2025年第22期4813-4822,共10页Chinese Journal of Tissue Engineering Research

基　　金：地方高校省级大学生创新创业训练计划项目(S202310661302X),项目负责人:彭璐瑶。

摘　　要：背景:硒作为人体所需的微量非金属元素具有抗炎、抗氧化、抗菌、免疫调节和抗肿瘤等生物活性,已经在生物医学领域得到广泛应用。目的:总结硒及其纳米颗粒在抗炎、抗氧化、抗菌、免疫调节和抗肿瘤方面的功能和作用机制,以及在口腔医学领域的研究进展。方法:以“selenium,selenium nanoparticles,oral neoplasms,caries,dental pupal disease,periapical disease,dental implant”为英文检索词,以“硒,硒纳米颗粒,口腔癌,龋病,牙髓病,根尖周病,口腔种植”为中文检索词,分别在PubMed、中国知网、万方数据库进行文献检索,检索文献时限为2000年1月至2024年2月。经过对文献的深入分析和仔细阅读,最后选择74篇文献进行全面综述。结果与结论:(1)硒的生物学特性主要是通过合成硒蛋白,以抗氧化机制为核心,调节各种细胞因子和介导与之相关的信号通路,进而产生抗菌、免疫调节、抗肿瘤等作用;(2)硒除了在口腔癌、龋病、牙髓根尖周病等方面可用于早期诊断、治疗和预后判断外,更多的是可作为新型口腔材料在口腔领域应用,例如:用于开发新型牙科封闭剂或根管系统消毒剂,又或在优化口腔种植材料性能等方面有所应用;(3)生物安全性是影响硒在生物医药领域应用的最重要因素之一,选择合适的剂量和形式才能使其发挥出良好作用。硒在口腔材料学方面展现出了巨大的应用潜力和广阔的发展空间。BACKGROUND:As an essential trace non-metallic element in the human body,selenium has been widely used in the biomedical field due to its potential anti-inflammatory,antioxidant,antibacterial,immunomodulatory,anti-tumor and other biological activities.OBJECTIVE:To summarize the anti-inflammatory,antioxidant,antibacterial,immunomodulatory,and anti-tumor effects and mechanisms of selenium and selenium nanoparticles,and research progress in the field of stomatology.METHODS:Literature searches were conducted on PubMed,CNKI,and WanFang databases using Chinese and English search terms“selenium,selenium nanoparticles,oral neoplasms,caries,dental pupal disease,periapical disease,dental implant.”The searched relevant articles were published from January 2000 to February 2024.After thoroughly analyzing and reading,74 articles were ultimately included for review.RESULTS AND CONCLUSION:(1)The biological characteristics of selenium are mainly achieved through the synthesis of selenoproteins,with antioxidant mechanisms as the core,regulating various cytokines and mediating related signaling pathways,thereby producing antibacterial,immune regulatory,and antitumor effects.(2)In addition to being used for early diagnosis,treatment,and postoperative judgment in oral cancer,caries,pulp and periapical diseases,selenium can also be used as a new type of material in the oral field.For example,it can be used to develop new dental sealants or root canal system disinfectants.Besides,it has a promoting effect on optimizing the performance of oral implant materials.(3)One of the most significant factors that affect the application of selenium in the field of biomedicine is biological safety.Only by selecting the appropriate dosage and form can it maximize its effects.Selenium has also shown great potential for application as well as broad development space in oral materials science.

关 键 词：硒 硒纳米颗粒 口腔癌 龋病 牙髓根尖周病 口腔种植 

分 类 号：R459.9[医药卫生—治疗学] R318.08[医药卫生—临床医学] R781.05