m^(6)A调控细胞自噬和铁死亡途径影响肿瘤细胞生长  

Regulation of Autophage and Ferroptosis by m^(6)A to Affect the Growth of Tumor Cell

作　　者：李名杨 陶爽 李国辉[1] LI Ming-Yang;TAO Shuang;LI Guo-Hui(Jiangsu University,School of Life Sciences,Department of Biological Sciences,Jiangsu,Zhenjiang 212013,China;Wujin Hospital Affiliated with Jiangsu University,Department Breast Surgery,Jiangsu,Changzhou 213164,China)

机构地区：[1]江苏大学,生命科学学院,生物科学系,江苏镇江212013 [2]江苏大学附属武进医院,乳腺外科,江苏常州213164

出　　处：《中国生物化学与分子生物学报》2024年第9期1222-1229,共8页Chinese Journal of Biochemistry and Molecular Biology

基　　金：国家自然科学基金(No.32072794);江苏大学医教协同创新基金重点项目(No.JDY2022011)资助。

摘　　要：N6-甲基腺苷(m^(6)A)修饰是RNA中腺苷酸(A)第6位N上发生的甲基化,是真核生物mRNA中最丰富的表观转录组学修饰。m^(6)A修饰不仅能调控胞内基因组转录水平,也直接影响癌基因、抑癌基因和多种非编码RNA(ncRNA)的表达水平,与肿瘤的发生、发展直接相关;另外,m^(6)A修饰也能调控细胞自噬和铁死亡代谢途径中相关基因的表达水平,从而调控细胞自噬和铁死亡等胞内代谢途径,其调控异常直接影响肿瘤细胞的增殖或者死亡。本文主要对m^(6)A修饰调控细胞自噬和铁死亡途径相关基因的表达,及其与肿瘤发生、发展相关的基因表达调控,促进或抑制体内肿瘤细胞的生长进行综述,不仅为进一步揭示肿瘤的发生、发展机制提供参考,也为肿瘤治疗提供新的靶标提供科学依据。N6-methyladenosine(m^(6)A)modification involves the methylation of the sixth nitrogen atom on the base A of RNA molecules.It is the most common and abundant RNA epigenetic modification in eukaryotic organism.It could not only directly affect the transcriptional level of intracellular genome,but also regulate the expression level of oncogenes,tumor suppressor genes and some ncRNA genes.Additionally,some autophagy-related genes and ferroptosis metabolism pathway-related genes were also reported to be regulated by m^(6)A.The abnormal regulation and dysfunction of target genes by m^(6)A usually promote or inhibit the growth of tumor cells.Therefore,the regulation of cellular autophagy and ferroptosis by m^(6)A to affect the growth of tumor was summarized in the study.It will be useful to demonstrate the mechanism of tumorigenesis and provide scientific basis for the development of a novel target on the treatment of tumor.

关 键 词：N6-甲基腺苷 细胞自噬 铁死亡 肿瘤 

分 类 号：Q522[生物学—生物化学]