靶向Wnt信号通路的小分子化合物抗骨肉瘤的作用机制研究进展  

Research progress in action mechanism of small molecular compounds targeting Wnt signaling pathway against osteosarcoma

作　　者：张雪 刘嘉玲 刘爽[1] ZHANG Xue;LIU Jialing;LIU Shuang(School of Basic Medicine,Jiamusi University,Jiamusi 154007,China)

机构地区：[1]佳木斯大学基础医学院,黑龙江佳木斯154007

出　　处：《中国药理学与毒理学杂志》2024年第9期694-700,共7页Chinese Journal of Pharmacology and Toxicology

基　　金：黑龙江省教育厅基本科研业务费基础研究项目(2020-KYYWF-0280);佳木斯大学博士专项科研启动基金(JMSUBZ2019-02)。

摘　　要：骨肉瘤(OS)是儿童和青少年中最常见的原发性恶性骨肿瘤,目前的治疗方式主要包括免疫治疗、基因治疗、靶向治疗和化疗等,但预后效果较差,且易复发和转移。Wnt信号通路参与OS的发生、发展、转移和预后的整个过程,使其成为一个有吸引力的靶点。目前针对Wnt信号通路相关的小分子化合物的研究正逐渐深入并得到广泛关注,使用小分子化合物靶向Wnt信号通路成为一种较有前景的OS治疗策略。本文围绕Wnt信号通路重点介绍Wnt信号通路与OS的关系,对靶向Wnt信号上下游的小分子化合物及其分类和作用机制进行分析和总结。靶向Wnt信号通路、明确具体机制并充分了解Wnt信号的复杂性将有助于完善临床上OS治疗方案的制定,为围绕Wnt信号通路调控开发抗肿瘤药物提供借鉴及思路。Osteosarcoma is the most common primary malignant bone tumor in children and adoles⁃cents.The current treatment methods include immunotherapy,gene therapy,targeted therapy and chemotherapy,but the prognosis is poor and prone to recurrence and metastasis.There is increasing evidence that the Wnt signaling pathway is involved in the entire process of osteosarcoma occurrence,development,metastasis,and prognosis,making it an attractive target.Current research on small molecule compounds related to the Wnt signaling pathway is making progress and attracting more attention so that targeting the Wnt signaling pathway with small molecule compounds has become a promising therapeutic strategy for osteosarcoma.This review focused on the Wnt signaling pathway and introduced the relationship between the Wnt signaling pathway and osteosarcoma,targeting small molecule compounds upstream and downstream of Wnt signaling,analyzed the classification and mechanism of action of related small molecule compounds,and summarized research progress.Targeting the Wnt signaling pathway,clarifying the specific mechanism,and an intimate knowledge of the complexity of Wnt signaling will help improve the formulation of clinical treatment plans for osteosarcoma,providing references and ideas for the development of anti-tumor drugs related to Wnt regulation.

关 键 词：小分子化合物 WNT信号通路 骨肉瘤 

分 类 号：R96[医药卫生—药理学] R915[医药卫生—药学]