五子衍宗丸治疗男性少弱精子症的Meta分析  

Wuzi Yanzong Pill in the Treatment of Male Oligoasthenospermia:A Meta-Analysis

作　　者：段锦龙 马卫国[1] DUAN Jinlong;MA Weiguo(Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China)

机构地区：[1]中国中医科学院广安门医院,北京100053

出　　处：《云南中医药大学学报》2024年第4期106-112,共7页Journal of Yunnan University of Chinese Medicine

基　　金：吴阶平医学基金会资助项目(320.6750.18055)。

摘　　要：目的系统评价五子衍宗丸治疗少弱精子症的有效性。方法检索CNKI、Wanfang Database、VIP、CBM、Pubmed、Cochrane Library、Embase数据库中五子衍宗丸治疗少弱精子症的随机对照试验,检索时限为自建库-2022年7月31日,对文献进行筛选、资料提取,评估偏倚风险,采用RevMan 5.3软件进行Meta分析。结果最终共纳入16项研究,包含1960例患者,依据干预措施进行亚组分析,Meta分析结果显示,五子衍宗丸组治疗后在精子密度[MD=5.28,95%CI(1.55,9.02),P=0.006]、A级精子[MD=6.69,95%CI(5.01,8.38),P<0.00001]、A+B级精子[MD=10.57,95%CI(7.28,13.85),P<0.00001]、配偶妊娠率[RR=1.25,95%CI(1.13,1.39),P<0.00001]、总有效率[RR=1.46,95%CI(1.3,1.63),P<0.00001]均显著高于西药组;联合用药组治疗后在精液量[MD=0.88,95%CI(0.71,1.04),P<0.00001]、精子密度[MD=7.19,95%CI(1.92,12.46),P=0.007]、A级精子[MD=7.9,95%CI(4.59,11.2),P<0.00001]、A+B级精子[MD=8.52,95%CI(3.99,13.04),P=0.0002]、配偶妊娠率[RR=1.79,95%CI(1.31,2.44),P=0.0003]、总有效率[RR=1.23,95%CI(1.12,1.35),P<0.00001]均显著高于西药组。结论五子衍宗丸单用或联合西药在改善精子密度、A级精子、A+B级精子、配偶妊娠率、总有效率指标上优于西药。Objective To systematically evaluate the effectiveness of Wuzi Yanzong pills in the treatment of oligoasthenospermia.Methods CNKI,Wanfang Database,VIP,CBM,Pubmed,Cochrane Library and Embase databases were searched for the randomized controlled trials of Wuzi Yanzong pill in treatment of oligonasthenospermia.The search time was from the self-established database to July 31,2022.Literature screening and data extraction were performed to assess the risk of bias,and Meta-analysis was performed using RevMan 5.3 software.Results A total of 16 studies were included,including 1960 patients,and subgroup analysis was performed according to the intervention measures.The results of Meta-analysis showed that after treatment,sperm density[MD=5.28,95%CI(1.55,9.02),P=0.006],grade A sperm[MD=6.69,95%CI(5.01,8.38),P<0.00001]and grade A+B sperm[MD=10.57,95%CI(7.28,13.85),P<0.00001]pregnancy rates,spouse[RR=1.25,95%CI(1.13,1.39),P<0.00001),the total effective rate(RR=1.46,95%CI(1.3,1.63),P<0.00001]were significantly higher than those in western medicine group.Combination group after treatment in semen volume[MD=0.88,95%CI(0.71,1.04),P<0.00001),sperm density[MD=7.19,95%CI(1.92,12.46),P=0.007),grade A sperm[MD=7.9,95%CI(4.59,11.2),P<0.00001),A+B grade sperm[MD=8.52,95%CI(3.99,13.04),P=0.0002),spouses pregnancy rate(RR=1.79,95%CI(1.31,2.44),P=0.0003),the total effective rate(RR=1.23,95%CI(1.12,1.35),P<0.00001)were significantly higher than western medicine group.Conclusion Wuzi Yanzong pill alone or combined with western medicine is superior to western medicine in improving sperm density,grade A sperm,grade A+B sperm,conjugal pregnancy rate and total effective rate.

关 键 词：少弱精子症 男性不育症 五子衍宗丸 META分析 

分 类 号：R277.5[医药卫生—中医学]