Single-Arm Clinical Study of Combination Perindopril-Amlodipine Tablets in the Treatment of High-Altitude Hypertension  

作　　者：Miao Shao Jin Tian Jacinda Huang Wentao Wu 

机构地区：[1]Department of Sports Medicine and Adult Reconstructive Surgery,Nanjing Drum Tower Hospital,the Affiliated Hospital of Nanjing University Medical School,Nanjing 210008,Jiangsu Province,China [2]Dulwich College Shanghai Puxi,Shanghai 201111,China [3]Jiangsu Leeway Biological Technology Co.,Ltd.,Nanjing 210008,Jiangsu Province,China

出　　处：《Journal of Clinical and Nursing Research》2024年第9期168-173,共6页临床护理研究（英文）

摘　　要：Objective:To evaluate the efficacy of combination perindopril/amlodipine tablets in patients with high-altitude hypertension who were previously unable to control their blood pressure with monotherapy.Methods:A total of 151 patients with high-altitude hypertension whose blood pressure remained inadequately controlled with previous monotherapy were enrolled in this study.All patients received an 8-week treatment with a combination of perindopril/amlodipine tablets,consisting of perindopril 10 mg/day and amlodipine 5 mg/day.Blood pressure measurements,including both diastolic and systolic pressures,were taken at baseline,and after 2,4,6,and 8 weeks of treatment.Results:After 8 weeks of treatment,there was a significant reduction in both average systolic and diastolic blood pressure compared to baseline(P<0.0001).Specifically,the average systolic blood pressure decreased by 24.45±13.75 mmHg,and the average diastolic blood pressure decreased by 13.37±8.40 mmHg.The overall heart rate showed no significant changes during the treatment period.Conclusion:A combination of perindopril/amlodipine tablets significantly improved blood pressure control in patients with high-altitude hypertension after 8 weeks of treatment.These results support the efficacy of combination perindopril/amlodipine as a viable treatment option for high-altitude hypertension.

关 键 词：High-altitude hypertension Perindopril/amlodipine Blood pressure control Systolic and diastolic pressure reduction 

分 类 号：R54[医药卫生—心血管疾病]