双嘧达莫对川崎病患儿临床指标的影响  

Effect of dipyridamole on clinical indicators in children with Kawasaki disease

作　　者：程渊博 任树萍 王利红 吴迎爽 薛向东 Cheng Yuanbo;Ren Shuping;Wang Lihong;Wu Yingshuang;Xue Xiangdong(Department of Pediatrics,Zhangjiakou First Hospital,Zhangjiakou 075000,Hebei,China)

机构地区：[1]张家口市第一医院儿科,河北张家口075000

出　　处：《血管与腔内血管外科杂志》2024年第7期812-815,825,共5页Journal of Vascular and Endovascular Surgery

基　　金：河北省卫生健康委科研基金项目(20221872)。

摘　　要：目的探讨双嘧达莫对川崎病患儿临床指标的影响。方法收集2019年1月至2023年12月张家口市第一医院收治的80例川崎病患儿的临床资料,根据治疗方法的不同将80例川崎病患儿分为常规组(n=36,采用常规治疗)和观察组(n=44,在常规治疗的基础上应用双嘧达莫治疗)。比较两组患儿的主要症状消退时间、住院时间以及治疗1个疗程后血清炎性反应指标、凝血功能指标、免疫功能指标。结果观察组患儿的黏膜充血消退时间、颈淋巴结肿大消退时间、手足肿胀消退时间、退热时间和住院时间均短于常规组患儿,差异均有统计学意义(P﹤0.05)。治疗后,观察组患儿的C反应蛋白(CRP)水平、降钙素原(PCT)水平、白细胞介素-6(IL-6)水平、白细胞计数(WBC)、红细胞沉降率(ESR)、免疫球蛋白(Ig)G、IgM、补体C3水平、血小板(PLT)及纤维蛋白原(FIB)水平均低于常规组患儿,凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)均长于常规组患儿,差异均有统计学意义(P﹤0.05)。结论双嘧达莫可有效改善川崎病患儿的凝血功能,增强患儿的免疫功能,从而更加有效地拮抗炎性反应,促进症状尽快缓解。Objective To investigate the effect of dipyridamole on clinical indicators in children with Kawasaki disease.Method The clinical data of 80 children with Kawasaki disease admitted to Zhangjiakou First Hospital from January 2019 to December 2023 were collected.According to different treatment methods,the 80 children with Kawasaki disease were divided into conventional group(n=36,treated with conventional therapy)and observation group(n=44,treated with dipyridamole on the basis of conventional treatment).The main symptom resolution time,hospitalization time,the serum inflammatory response indicators,coagulation function indicators,immune function indicators after one course of treatment between two groups of children were compared.Result The observation group had shorter time for mucosal congestion resolution,neck lymph node swelling resolution,hand and foot swelling resolution,fever resolution,and hospitalization compared to the control group,and the differences were statistically significant(P<0.05).After treatment,the level of C-reactive protein(CRP),procalcitonin(PCT),the level of interleukin-6(IL-6),white blood cell count(WBC),erythrocyte sedimentation rate(ESR),the level of immunoglobulin(Ig)G,the level of IgM,and the level of complement C3,platelet(PLT)and level of fibrinogen(FIB)of the observation group were lower than those of the conventional group,while the prothrombin time(PT)and activated partial thrombin time(APTT)were longer than those in the conventional group,and the differences were statistically significant(P<0.05).Conclusion Dipyridamole can effectively improve the coagulation function and enhance the immune function of children with Kawasaki disease,thereby more effectively antagonizing the inflammatory response of children and promoting symptom relief as soon as possible.

关 键 词：川崎病 双嘧达莫 全身性血管炎 凝血功能 免疫功能 

分 类 号：R543[医药卫生—心血管疾病]