基于超声-光声多模态成像仪器的骨结构及成分高分辨率表征方法  

High-resolution characterization of bone structure and composition based on an ultrasonic-photoacoustic multimodal imaging instrument

作　　者：谢强 李博艺 杨春山 韩帅 他得安 Xie Qiang;Li Boyi;Yang Chunshan;Han Shuai;Ta De′an(School of Information Science and Technology,Fudan University,Shanghai 200433,China;Institute of Biomedical Engineering and Technology,Academy for Engineering and Technology,Fudan University,Shanghai 200433,China)

机构地区：[1]复旦大学信息科学与工程学院,上海200433 [2]复旦大学工程与应用技术研究院生物医学工程技术研究所,上海200433

出　　处：《仪器仪表学报》2024年第6期177-187,共11页Chinese Journal of Scientific Instrument

基　　金：国家自然科学基金(11827808,12104096);中国博士后科学基金(2021M690709)项目资助。

摘　　要：早期诊断和治疗骨质疏松症能显著降低骨折风险。骨组织物理结构和生化成分的影像学检查对骨质疏松症的诊断具有重要意义。为了克服基于射线的骨骼健康检查技术存在电离辐射,无法表征骨组织生化成分等问题,本文设计了一套超声-光声多模态成像仪器。该仪器由波长实时可调的激光器、多模时序控制器、超声数据采集与控制器、高速数据交换与传输模块组成,利用时分复用和异步成像策略原位采集超声和光声信号,结合高分辨率成像算法获得骨组织的超声-光声影像。松质骨仿体和牛松质骨的离体试验以及手指关节在体试验结果表明,所提出的超声-光声多模态成像仪器在骨质疏松症的诊断中具有潜在的应用价值,为全面评价骨骼健康的临床研究奠定了基础。Early diagnosis and treatment of osteoporosis can significantly reduce the risk of fractures.The imaging examinations of bone tissue′s physical structure and biochemical composition play an important role in the diagnosis of osteoporosis.In order to overcome the limitations of X-ray-based bone health examination techniques,such as ionizing radiation and inability to characterize the biochemical composition of bone tissue,this article designs an ultrasonic-photoacoustic multimodal imaging instrument.This instrument integrates a real-time wavelength-tunable laser,a multi-mode timing controller,an ultrasound data acquisition and controller,and a high-speed data exchange and transmission module.It utilizes time-division multiplexing and asynchronous imaging strategies to process ultrasound and photoacoustic signals in situ.By combining high-resolution imaging algorithms,it obtains ultrasonic-photoacoustic images of bone tissue.In vitro experiments of cancellous bone phantoms and bovine trabecular bone,as well as in vivo experiments of finger joints,demonstrate that the proposed ultrasonic-photoacoustic dual-mode imaging technology has potential application in the diagnosis of osteoporosis,laying a solid foundation for comprehensive clinical research on bone health evaluation.

关 键 词：骨质疏松 超声-光声成像仪 骨结构及成分表征 高分率骨成像 

分 类 号：TH781[机械工程—仪器科学与技术]