^(99)Tc^(m)-焦膦酸盐在心脏淀粉样变中的分型诊断应用  

Application of ^(99)Tc^(m)-pyrophosphate for typological diagnosis in cardiac amyloidosis

作　　者：刘双立 李剑波[1] 王雪梅[1] Liu Shuangli;Li Jianbo;Wang Xuemei(Department of Nuclear Medicine,the Affiliated Hospital of Inner Mongolia Medical University,Key Laboratory of Molecular Imaging,Inner Mongolia Autonomous Region,Hohhot 010050,China)

机构地区：[1]内蒙古医科大学附属医院核医学科、内蒙古自治区分子影像学重点实验室,呼和浩特010050

出　　处：《中华核医学与分子影像杂志》2024年第9期568-571,共4页Chinese Journal of Nuclear Medicine and Molecular Imaging

基　　金：内蒙古自治区科技计划基金(2022YFSH0058)。

摘　　要：淀粉样变性病是一种代谢性疾病, 以多器官淀粉样蛋白原纤维沉积为特征, 引起组织结构紊乱, 导致器官功能下降, 累及心肌时可引起心脏结构和功能受损, 而心脏受累是导致死亡率的主要原因。但由于该病起病隐匿, 临床表现缺乏特异性, 致使该疾病经常被误诊或漏诊。^(99)Tc^(m)-焦膦酸盐(PYP)SPECT作为无创性检查手段不仅能早期识别心脏淀粉样蛋白物质沉积, 还能为疾病的分型及预后评估提供重要信息。该文将简述心脏淀粉样变的常规检查手段, 概述其存在的局限性, 并重点介绍^(99)Tc^(m)-PYP SPECT显像对心脏淀粉样变的临床诊断价值。Amyloidosis is a metabolic disease characterized by the deposition of amyloidogenic fibrils in multiple organs,which causes structural disorders,leading to a decline in organ function and in the case of myocardial involvement,damage to the structure and function of the heart,which is the main cause of mortality.However,the disease is often misdiagnosed or underdiagnosed due to its insidious onset and lack of specificity in clinical manifestations.^(99)Tc^(m)-pyrophosphate(PYP)SPECT is a noninvasive test that can not only identify cardiac amyloid deposits at an early stage but also provide a useful tool for the diagnosis of cardiac amyloidosis.This article briefly describes the traditional screening methods for cardiac amyloidosis,outlines their limitations,and focuses on the clinical diagnostic value of ^(99)Tc^(m)-PYP SPECT in cardiac amyloidosis.

关 键 词：淀粉样变性 心肌 放射性核素显像 99m锝焦磷酸盐 发展趋势 

分 类 号：R541[医药卫生—心血管疾病]