妊娠晚期妇女生殖道B族链球菌定植对母婴健康的影响  

Effects of Colonization of Group B Streptococcus in Reproductive Tract on Maternal and Infant Health in Late Pregnancy

作　　者：林柏珠 LIN Baizhu(Department of Obstetrics,Fujian Longyan People's Hospital,Longyan 364000,China)

机构地区：[1]福建省龙岩人民医院产科,龙岩364000

出　　处：《中国医药指南》2024年第27期100-103,共4页Guide of China Medicine

摘　　要：目的以妊娠晚期妇女作为观察对象,就其生殖道B族链球菌定植对母婴健康的临床影响进行详细分析和探讨。方法本文的观察对象为福建省龙岩市人民医院收治的362例妊娠晚期妇女,观察对象的选取时间为2021年1月至2022年1月,通过实时荧光定量PCR方法检测所有观察对象的生殖道B族链球菌定植情况,根据检测结果将观察对象分为阳性组与阴性组,两组的孕妇例数分别为180例、182例,对比两组的生殖道微生态情况、不良妊娠结局发生情况、不良新生儿结局发生情况。结果在白带清洁分度占比情况、阴道pH值、生殖道菌群失调占比情况的比较上,阳性组与阴性组均存在明显差异(P<0.05)。阳性组早产、胎膜早破、宫内感染、羊水污染、胎儿窘迫、产后出血发生率均高于阴性组(P<0.05)。阳性组新生儿高胆红素血症、新生儿肺炎、新生儿窒息、新生儿感染、新生儿败血症发生率均高于阴性组(P<0.05)。结论对于妊娠晚期妇女而言,生殖道B族链球菌定植与其生殖道的微生态失调存在密切联系,若不及时给予有效干预,会在一定程度上增加不良妊娠结局与不良新生儿结局的发生风险,危及母婴健康。Objective The clinical effects of group B streptococcus colonization on maternal and infant health were analyzed and discussed in detail in the late pregnancy women.Methods The observation objects in this study were 362 women in the late pregnancy treated in the Longyan People's Hospital.The observation objects were selected from January 2021 to January 2022.The colonization of reproductive tract group B streptococcus of all the observation objects was detected by real-time fluorescent quantitative PCR method,and the observation objects were divided into positive group and negative group according to the detection results,the number of pregnant women in the two groups was 180 and 182 respectively.The reproductive tract microecology,adverse pregnancy outcomes and adverse neonatal outcomes of the two groups were compared.Results There were significant differences between the positive group and the negative group in the cleaning proportion of leucorrhea,vaginal pH value and the proportion of reproductive tract bacteria imbalance(P<0.05).Compared with negative group,the incidence of preterm labor,premature rupture of membranes,intrauterine infection,amniotic fluid contamination,fetal distress and postpartum hemorrhage were higher in positive group(P<0.05).Compared with negative group,the incidence of neonatal hyperbilirubinemia,neonatal pneumonia,neonatal asphyxia,neonatal infection and neonatal sepsis were higher in positive group(P<0.05).Conclusions For women in the third trimester of pregnancy,the colonization of group B streptococcus in the reproductive tract is closely related to the microecological imbalance of the reproductive tract.If not given effective intervention in time,it will increase the risk of adverse pregnancy outcomes and adverse neonatal outcomes to a certain extent,endangering maternal and infant health.

关 键 词：B族链球菌 妊娠晚期 生殖道微生态 妊娠结局 新生儿结局 

分 类 号：R714.25[医药卫生—妇产科学]