中药鞣质类成分治疗代谢性疾病研究进展  

Research Progress of Tannins in the Treatment of Metabolic Diseases

作　　者：张杰 魏颖[2] 苏丽娅 张海峰[1] ZHANG Jie;WEI Ying;SU Liya;ZHANG Haifeng(Basic Medical College of Inner Mongolia Medical University,Hohhot O10110,China;Inner Mongolia Medical University Affiliated Hospital Clinical Medical Research Center,Hohhot 010110,China)

机构地区：[1]内蒙古医科大学基础医学院,呼和浩特010110 [2]内蒙古医科大学附属医院临床医学研究中心,呼和浩特010110

出　　处：《世界科学技术-中医药现代化》2024年第6期1546-1552,共7页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：内蒙古自治区自然科学基金委员会青年基金项目(2021BS08003):蒙药“阿古特-其其格”改善肥胖缺氧引起的胰岛素抵抗作用及其机制研究,负责人:魏颖;内蒙古医科大学学术委员会“科技百万工程”联合项目(YKD2020KJBW(LH)032):基于RAGE/NF-κB通路蒙药“阿如拉”改善缺氧3T3-L1细胞胰岛素抵抗作用研究,负责人:魏颖;内蒙古医科大学附属医院科研部重点实验室开放基金项目(2022NYFYSYS012):蒙药古日古木-13抑制非酒精性脂肪性肝病的可能机制,负责人:张海峰。

摘　　要：代谢性疾病是指糖尿病、高脂血症、高尿酸血症及肝病等机体的物质代谢或能量代谢异常而表现出代谢性紊乱性疾病。近年随着国民饮食结构的改变其发病率逐年上升,严重危害国民身心健康。现代医学对代谢性疾病的治疗多采用化药长期治疗,治疗过程中容易产生药物耐药及肝肾损伤等问题。鞣质是由葡萄糖、没食子酸、黄烷醇等组成的一类多元酚类化合物,具有抑菌、抗肿瘤、抗氧化、降血糖、抗病毒、抗炎镇痛等生物活性作用,对代谢性疾病有明确缓解作用。且鞣质治疗代谢性疾病具有毒副作用小、疗效显著、成本低、易于推广等优点,为代谢性疾病的治疗提供了更优选择。本研究旨在对中药鞣质成分治疗代谢性疾病的研究综述,结合鞣质本身化学结构、生物活性,归纳鞣质在治疗代谢性疾病中的作用,以期为鞣质药用资源的充分利用提供理论依据。Metabolic diseases refer to metabolic disorders caused by abnormal material metabolism or energy metabolism of the body such as diabetes,hyperlipidemia,hyperuricemia and liver disease.In recent years,with the change of national diet structure,its incidence has increased year by year,which seriously endangers national physical and mental health.In modern medicine,long-term treatment of metabolic diseases is often used in the treatment of chemical drugs,which is easy to produce drug resistance and liver and kidney damage.Tannin is a class of polyphenolic compounds composed of glucose,gallic acid,flavanols,etc.,which has antibacterial,anti-tumor,anti-oxidation,hypoglycemic,antiviral,anti-inflammatory and analgesic effects,and has a clear easing effect on metabolic diseases.Tannin in the treatment of metabolic diseases has the advantages of less toxic side effects,significant curative effect,low cost,easy to popularize,etc.,which provides a better choice for the treatment of metabolic diseases.

关 键 词：中药鞣质 代谢性疾病 基础研究 研究进展 

分 类 号：R285[医药卫生—中药学]