白细胞介素-17在主要细菌性人兽共患病中的作用及其机制  

Roles of interleukin-17 in major bacterial zoonoses and its mechanisms

作　　者：刘爱军[1] 黄晓兵[1] 周彩琴[1] 张传亮[1] LIU Aijun;HUANG Xiaobing;ZHOU Caiqin;ZHANG Chuanliang(Zhejiang Center of Animal Disease Prevention and Control,Hangzhou 311199,China)

机构地区：[1]浙江省动物疫病预防控制中心,浙江杭州311199

出　　处：《中国兽医学报》2024年第6期1316-1324,共9页Chinese Journal of Veterinary Science

基　　金：浙江省农业重大技术协同推广资助项目(2021XTTGXM05)。

摘　　要：白介素-17(IL-17)是重要的促炎细胞因子,能够连接先天性免疫和适应性免疫,介导对病原感染的保护性免疫,然而一旦分泌失调又会促进炎症病理损伤和自身免疫性疾病。在多种细菌性人兽共患病中,IL-17都具有重要的保护作用,促进了各种器官组织炎性疾病的发生发展,并与细菌感染诱导的自身免疫性疾病相关。近期的研究表明,细菌感染中分泌IL-17的CD4+组织驻留记忆T细胞在维持适应性免疫中发挥着关键作用,靶向IL-17反应的疫苗设计策略对于提高疫苗效力具有明显优势。为此,本文综述了IL-17的生物学功能及其在主要细菌性人兽共患病中的作用和相关机制,以期为开发安全有效的基于IL-17的免疫疗法提供参考。Interleukin-17(IL-17)is an important pro-inflammatory cytokine that bridges innate and adaptive immunity,promoting protective immunity against pathogens,but also driving inflammatory pathology during infection and autoimmunity.IL-17 has important protective roles in a variety of bacterial zoonoses,but also promotes the development of inflammatory diseases in various organ tissues and is associated with autoimmune diseases induced by bacterial infections.Recent studies have shown that IL-17-secreting CD4~+tissue-resident T memory cells play a key role in sustaining adaptive immunity to bacterial infections,and vaccine design strategies targeting IL-17 responses exhibit apparent advantages in improving vaccine efficacy.In this regard,this paper reviews the biological functions of IL-17 and its roles in major bacterial zoonoses and related mechanisms,with the aim of providing a reference for the development of safe and effective IL-17-based immunotherapies.

关 键 词：IL-17 细菌 人兽共患病 免疫 

分 类 号：S852.4[农业科学—基础兽医学] R535[农业科学—兽医学]