基于Fe/Ni二元金属有机框架/多壁碳纳米管的电化学传感器对芬太尼的快速检测  

Rapid Detection of Fentanyl by Electrochemical Sensor Based on Fe/Ni Binary Metal-Organic Frameworks/Multi-Walled Carbon Nanotubes

作　　者：赵志东 何缘 祁星瑞 靳焘[1,2,4] ZHAO Zhi-Dong;HE Yuan;QI Xing-Rui;JIN Tao(Chinese Academy of Sciences Engineering Laboratory for Special Fine Chemicals,Guangzhou Institute of Chemistry,Chinese Academy of Sciences,Guangzhou 510650,China;University of Chinese Academy of Sciences,Beijing 101408,China;Guizhou University Risk Prevention and Control Research Center,Department of Investigation,Guizhou Police College,Guiyang 550005,China;Chinese Academy of Sciences Testing Technical Services(Guangzhou)Co.Ltd.,Guangzhou 510650,China;Department of Public Instruction,Guangdong Industry Polytechnic University,Guangzhou 510300,China)

机构地区：[1]中国科学院广州化学研究所,中国科学院特种精细化学品工程实验室,广州510650 [2]中国科学院大学,北京101408 [3]贵州警察学院侦查系,贵州省高校风险防控研究中心,贵阳550005 [4]中科检测技术服务(广州)有限公司,广州510650 [5]广东轻工职业技术大学公共课教学部,广州510300

出　　处：《分析化学》2024年第8期1152-1162,共11页Chinese Journal of Analytical Chemistry

基　　金：国家自然科学基金项目(No.42063002);贵州省科技支撑计划项目(No.黔科合支撑[2023]一般441);贵州省高校风险防控研究中心科研项目(No.23GZGXRWJD2543)资助。

摘　　要：芬太尼是一种强效麻醉性阿片类镇痛药物,在临床手术中可作为静脉麻醉剂,但同时也被吸毒人员作为毒品滥用,由此导致的死亡人数逐年增多,因此,亟需开发芬太尼的快速筛查方法。本研究以二元金属有机框架MIL-88B(Fe/Ni)作为电催化剂,结合多壁碳纳米管(MWCNTs)修饰玻碳电极(GCE)构建了电化学传感器用于芬太尼的快速检测。通过扫描电镜(SEM)、能量色散X射线光谱(EDS)、X射线衍射(XRD)以及X射线光电子能谱(XPS)等多种方法表征了所合成的MIL-88B(Fe/Ni)及MIL-88B(Fe/Ni)/MWCNTs复合材料的形貌、晶体结构和元素特征。电化学测试结果表明,MIL-88B(Fe/Ni)/MWCNTs复合材料修饰GCE具有较低的电化学阻抗和较大的电化学表面积,对芬太尼具有超高的灵敏度。在优化的实验条件下,对芬太尼的线性检测范围为0.04~10μmol/L,检出限(LOD,3Sb/M)为0.015μmol/L,重现性、选择性和稳定性均良好。进一步利用此修饰电极检测实际尿液和血液样品中的芬太尼含量,在0.2~1.0μmol/L浓度范围内,回收率分别为58.6%~81.5%和82.7%~97.5%。MIL-88B(Fe/Ni)/MWCNTs复合材料可作为一种新型电极修饰材料,用于芬太尼的电化学快速检测,在公安禁毒和医疗急救领域中具有巨大的应用潜力。As a potent narcotic opioid analgesic,fentanyl has been used as intravenous anesthesia for clinical procedures while also being abused by drug users,resulting in an increasing number of deaths year by year,and thus it is urgent to develop rapid screening methods for fentanyl.In this study,by using a binary metal-organic framework MIL-88B(Fe/Ni)as an electrocatalyst,an electrochemical sensor based on multi-walled carbon nanotubes(MWCNTs)modified glassy carbon electrode(GCE)was constructed for rapid detection of fentanyl.The morphology,crystal structure and elemental characteristics of the synthesized MIL-88B(Fe/Ni)/MWCNTs and MIL-88B(Fe/Ni)composites were confirmed by scanning electron microscopy(SEM),energy dispersive X-ray spectroscopy(EDS),X-ray diffraction(XRD)and X-ray photoelectron spectroscopy(XPS).In addition,the electrochemical characterization also revealed that the synthesized MIL-88B(Fe/Ni)/MWCNTs composites modified GCE possessed low electrochemical impedance and large electrochemical surface area with ultra-high sensitivity to fentanyl.The experimental conditions for the electrochemical detection of fentanyl were optimized and the limit of detection(LOD,3Sb/M)for fentanyl was 0.015μmol/L with a linear range of 0.04–10μmol/L,and the reproducibility,selectivity and stability were all favorable.In addition,the developed sensor showed satisfactoryperformance in real samples,with recoveriesranging from 58.6%to 81.5%andfrom 82.7%to 97.5%in urine and blood,respectively,at concentration levels of 0.2–1.0μmol/L.The proposed MIL-88B(Fe/Ni)/MWCNTs composite could be used as a novel electrode material for electrochemical detection of fentanyl,and had great potential for rapid detection of fentanyl in public security anti-drug or medical emergency.

关 键 词：芬太尼 MIL-88B(Fe/Ni) 多壁碳纳米管 电化学检测 差分脉冲伏安法 

分 类 号：R927.1[医药卫生—药学] O657.1[理学—分析化学]