常见消化系统疾病与继发性骨质疏松  

Common digestive diseases and secondary osteoporosis

作　　者：谭文彬 李佳 刘明玉 路永欣 程雅欣 TAN Wen-bin;LI Jia;LIU Ming-yu;LU Yong-xin;CHENG Ya-xin(Department of Endocrinology,General Hospital of Southern Theater Command of the People's Liberation Army,Guangzhou 510010,China;The First School of Clinical Medicine,Southern Medical University,Guangzhou 510515,China)

机构地区：[1]中国人民解放军南部战区总医院内分泌科,广州510010 [2]南方医科大学第一临床医学院,广州510515

出　　处：《中华骨质疏松和骨矿盐疾病杂志》2024年第4期386-396,共11页Chinese Journal Of Osteoporosis And Bone Mineral Research

基　　金：国家重点研发计划(2021YFC2501701);广东省中央引导地方科技发展专项基金(KTP20190249)。

摘　　要：骨质疏松症(osteoporosis,OP)是一种全身性的代谢性骨病,已成为备受现代社会广泛关注的公共健康问题之一。许多消化系统疾病有较高的OP发生率,主要包括消化性溃疡、炎症性肠病、慢性肝炎、肝硬化、胃肠道肿瘤等。但目前对这些疾病引起骨质疏松的机理尚未完全明确。同时部分抗OP药物多表现胃肠道相关不良反应,可能加重患者临床症状,因此,寻求有效的治疗策略是当务之急。本文分别从流行病学特征、相关危险因素与发病机制、骨代谢变化与骨损害特点及诊治进展四方面对临床消化系统常见引起继发性骨质疏松的疾病进行综述,以期为继发性骨质疏松防治及推进多学科协作模式发展提供参考。Osteoporosis(OP)is a systemic metabolic bone disease,which has become one of the public health problems of the society.Many digestive diseases have a high risk of OP,including inflammatory bowel disease,chronic hepatitis,liver cirrhosis,gastrointestinal tumors and so on.At present,the mechanism of these diseases causing osteoporosis is not fully understood.At the same time,some anti-osteoporosis drugs often show gastrointestinal side effects,which may aggravate the clinical symptoms of patients.Therefore,it is urgent to seek effective treatment strategies.This article reviews the epidemiological characteristics,related risk factors,bone metabolism changes and bone damage characteristics,pathogenesis and diagnosis and treatment progress of secondary osteoporosis caused by digestive system common diseases,in order to provide reference for the prevention and treatment of secondary osteoporosis and to promote the development of multidisciplinary collaboration model.

关 键 词：消化系统疾病 骨质疏松症 发病机制 

分 类 号：R681[医药卫生—骨科学] R57[医药卫生—外科学]