亨尼帕病毒编码蛋白的特征及致病机制  

Progress on the Characteristics of Virus-encoded Proteins and Pathogenic Mechanism of Henipavirus

作　　者：汪芳洲 谭凌云 李燕 谷宏婧 王慧 WANG Fangzhou;TAN Lingyun;LI Yan;GU Hongjing;WANG Hui(Institute of Public Health,Mudanjiang Medical College,Mudanjiang 157011,China;State Key Laboratory of Pathogens and Biosecurity,Institute of Microbiology and Epidemiology,Academy of Military Medical Sciences,Beijing 100071,China)

机构地区：[1]牡丹江医学院公共卫生学院,牡丹江157011 [2]军事科学院军事医学研究院微生物流行病研究所病原微生物生物安全全国重点实验室,北京100071

出　　处：《畜牧兽医学报》2024年第9期3802-3811,共10页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：北京市科技新星计划(20220484026)。

摘　　要：亨尼帕病毒(Henipavirus,HNV)是一类重要的新发人兽共患病原,经接触、口鼻传播感染可引发呼吸、神经系统疾病,死亡率高达75%。HNV属于副黏病毒科单股负链RNA包膜病毒,随着环境变化,新的亚型不断涌现,传播范围逐渐扩大,严重威胁全球公共卫生安全、经济发展与社会稳定。然而,其致病机制尚不清楚,预防疫苗及治疗药物也未上市,引起WHO高度关注,HNV疫苗与药物研发列入需要紧急研发蓝图清单。本文通过对HNV的病原学特征、编码蛋白的结构和功能、致病机制进行总结,为研制有效干预HNV感染的药物和疫苗提供思路。Henipavirus(HNV)is an important new class of zoonotic pathogens,which can cause respiratory and neurological diseases through contact,oral and nasal transmission,and the mortality rate is as high as 75%.HNV belongs to the negative stranded single-stranded RNA envelope virus of the paramyxoviridae family.With the change of environment,new virus subtypes continue to emerge and the spread of the scope gradually expands,which seriously threatens global public health security,economic development and social stability.However,the pathogenic mechanism of infection is not clear,and preventive vaccines and therapeutic drugs have not been marketed,which has aroused great concern from WHO,and the research and development of vaccines and drugs has been included in the list of blueprints that require urgent research and development.This review summarizes the etiological characteristics,structure and functions of the encoded proteins,and pathogenic mechanism of HNV,so as to provide ideas for the development of drugs and vaccines for effective intervention in HNV infection.

关 键 词：亨尼帕病毒 病原学 编码蛋白 致病机制 

分 类 号：S852.659.5[农业科学—基础兽医学]