归黄方治疗Ⅲ型前列腺炎精室湿热瘀滞证的临床研究  

Guihuang Formula for type III prostatitis with damp-heat stasis syndrome in the essence chamber:A clinical trial

作　　者：高庆和[1] 刘胜京 赵明 赵子维 郭博达 GAO Qing-he;LIU Sheng-jing;ZHAO Ming;ZHAO Zi-wei;GUO Bo-da(Department of Andrology,Xiyuan Hospital,Chinese Academy of Traditional Chinese Medicine,Beijing 100091,China;Department of Urology,Peking University Third Hospital,Beijing 100191,China)

机构地区：[1]中国中医科学院西苑医院男科,北京100091 [2]北京大学第三医院泌尿外科,北京100191

出　　处：《中华男科学杂志》2024年第8期738-743,共6页National Journal of Andrology

基　　金：国家自然科学基金青年项目(82104880);中国中医科学院优秀青年科技人才培养专项(ZZ16-YQ-010)。

摘　　要：目的:观察归黄方治疗Ⅲ型前列腺炎精室湿热瘀滞证的有效性与安全性。方法:纳入Ⅲ型前列腺炎精室湿热瘀滞证患者120例,随机分为试验组(归黄方)60例,对照组(盐酸坦索罗辛缓释胶囊)60例。连续服药6周,随访4周。观察治疗前后美国国立卫生研究院慢性前列腺炎临床症状积分指数(NIH-CPSI)、中医症状评分、前列腺按摩液常规,以及血尿常规、肝肾功能、心电图。结果:两组治疗后均可显著降低NIH-CPSI总评分、疼痛评分、排尿评分、生活质量影响评分、中医症状评分、WBC数量(P<0.05),增加卵磷脂小体数量(P<0.05)。试验组在治疗6周结束后,NIH-CPSI评分由(28.34±9.23)分降低为(6.78±3.53)分;对照组在治疗结束后,NIH-CPSI评分由(27.81±8.28)分降低为(14.48±4.27)分。试验组与对照组比较,除治疗第2周时排尿评分与对照组无明显差别以外(P>0.05),第4、6、10周时试验组在降低NIH-CPSI总评分、疼痛评分、排尿评分、生活质量影响评分及中医症状评分方面,均优于对照组(P<0.05)。试验组在减少WBC数目、增加卵磷脂小体数量方面优于对照组(P<0.05)。安全性检查两组治疗后均未见明显异常,治疗过程未见明显不良反应。结论:归黄方治疗Ⅲ型前列腺炎精室湿热瘀滞证安全、有效。Objective:To investigate the efficacy and safety of Guihuang Formula(GHF)in the treatment of type III prostatitis with the syndrome of damp-heat stasis in the essence chamber.Methods:This study included 120 cases of type III prostatitis with damp-heat stasis syndrome in the essence chamber,which were randomly and equally divided into a GHF and a control group,the former treated with GHF and the latter with Tamsulosin Hydrochloride Sustained-Release Capsules,both for 6 successive weeks.We followed up the patients for 4 weeks,recorded the NIH-CPSI,TCM symptom scores,and results of prostatic fluid routine,blood and urine routine,liver and kidney function and electrocardiogram examinations,and compared them between the two groups of patients before and after treatment.Results:Compared with the baseline,the total NIH-CPSI scores were significantly decreased in both the GHF and control groups after 6 weeks of treatment,even more significantly in the former group(28.34±9.23 vs 6.78±3.53,P<0.05)than in the latter(27.81±8.28 vs 14.48±4.27,P<0.05),so were the scores on pain,voiding symptoms,quality of life(QOL)impact,TCM symptoms and WBC count(all P<0.05),while the number of lecithin bodies remarkably increased(P<0.05).There were statically significant differences in the above parameters at 4,6 and 10 weeks of medication(P<0.05),but not at 2 weeks(P>0.05).No obvious abnormalities or adverse reactions were observed in either of the two groups during the treatment.Conclusion:Guihuang Formula is safe and effective in the treatment of type III prostatitis with the syndrome of damp-heat stasis in the essence chamber.

关 键 词：慢性前列腺炎 归黄方 临床试验 精室湿热瘀滞 

分 类 号：R697.33[医药卫生—泌尿科学] R242[医药卫生—外科学]