线粒体损伤与男性生殖功能障碍的研究进展  

Mitochondrial damage and male reproductive dysfunction:Progress in research

作　　者：李金东(综述) 刘振湘[2] 商学军(审校)[1] LI Jin-dong;LIU Zhen-xiang;SHANG Xue-jun(Department of Urology,Nanjing School of Clinical Medicine,Southern Medical University/General Hospital of Eastern Theater Command,Nanjing,Jiangsu 210002,China;Department of Urology,Haikou Hospital Affiliated to Central South University Xiangya School of Medicine,Haikou,Hainan 570100,China)

机构地区：[1]南方医科大学南京临床医学院/东部战区总医院泌尿外科,江苏南京210002 [2]中南大学湘雅医学院附属海口医院泌尿外科,海南海口570100

出　　处：《中华男科学杂志》2024年第8期744-749,共6页National Journal of Andrology

基　　金：海南省卫生健康行业科研项目(22A200318)。

摘　　要：线粒体是精子代谢的中心,是精子鞭毛运动、获能、顶体反应和配子融合等各个环节所必需的。精子中线粒体超微结构、膜电位、活性氧、Ca^(2+)平衡、精子凋亡、线粒体DNA、线粒体酶以及蛋白组活性等的异常均可引起精子质量下降,甚至导致男性不育。本文通过查阅分析线粒体与男性生殖功能的相关文献,阐述了线粒体功能异常对精子的影响,旨在为探讨新的治疗男性生殖功能障碍的有效干预措施提供理论依据。Mitochondria are the center of sperm metabolism and essential for all aspects of flagellar motility,capacitation,acrosome reaction and gametic fusion of sperm.Abnormalities in the mitochondrial ultrastructure,membrane potential,reactive oxygen species,Ca^(2+)homoeostasis,sperm apoptosis,mitochondrial DNA,mitochondrial enzymes and proteomic activity can decrease sperm quality and even cause male infertility.This paper elucidates the impact of mitochondrial dysfunction on sperm by reviewing and analyzing relevant literature on mitochondria and male reproductive function,aiming to provide some theoretical evidence for exploring effective interventions for male reproductive dysfunction.

关 键 词：线粒体 精子 男性不育 活性氧 凋亡 线粒体DNA 线粒体融合/分裂 

分 类 号：R698.2[医药卫生—泌尿科学]