机械力转导在抗病毒免疫反应中的作用  

Mechanotransduction in antiviral immune response

作　　者：王常英 张涛清 郑海学 伍国强[1] 秦晓东[2] WANG Changying;ZHANG Taoqing;ZHENG Haixue;WU Guoqiang;QIN Xiaodong(School of Life Science and Engineering,Lanzhou University of Technology,Lanzhou 730050,China;State Key Laboratory for Animal Disease Control and Prevention,College of Veterinary Medicine,Lanzhou University,Lanzhou Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Lanzhou 730046,China)

机构地区：[1]兰州理工大学生命科学与工程学院,甘肃兰州730050 [2]中国农业科学院兰州兽医研究所兰州大学动物医学与生物安全学院动物疫病防控国家重点实验室,甘肃兰州730046

出　　处：《中国兽医科学》2024年第9期1253-1258,共6页Chinese Veterinary Science

基　　金：国家重点研发计划项目(2021YFD1800300);甘肃省重大专项(22ZD6NA001);中国农业科学院创新计划项目(CAAS-CSLPDCP-2023002);2024创新工程项目(CAAS-ASTIP-2021-LVRI)。

摘　　要：细胞感受和传导机械力主要由LINC、Lamin A/C、Piezo1、TRPV4以及整合素等分子介导。越来越多的研究表明,机械力转导在免疫系统发育及免疫应答中发挥着重要的作用。在感染病原体以后,细胞免疫反应的激活、细胞因子的产生、代谢、增殖和运输都受到机械力转导的调控。本文就机械力转导对免疫应答、炎症反应以及免疫细胞功能调控的影响进行了详细总结。Cells are subjected to mechanical forces throughout their life cycle.This process is mediated by molecules such as LINC,Lamin A/C,TRPV4,and integrins.Recent studies have shown that mechanotransduction plays a crucial role in the development of the immune system and immune responses.After infection with pathogens,mechanotransduction regulates the activation of cellular immune responses,cytokine production,metabolism,proliferation,and transport.This review provides an in-depth analysis of the effects of mechanotransduction on the immune response,the inflammatory response,and the regulation of immune cell function.

关 键 词：LINC Lamin A/C Piezo1 TRPV4 免疫应答 

分 类 号：S852.42[农业科学—基础兽医学]