动物类中药抗肝纤维化作用机制的研究与思考  

Research and Reflection on Mechanism of Traditional Chinese Medicine of Animal Materials Against Hepatic Fibrosis

作　　者：靳兰昕 闵远骞 王凯旋 丁疏影 禄保平[1,2] JIN Lanxin;MIN Yuanqian;WANG Kaixuan;DING Shuying;LU Baoping(The Second Clinical Medical School of Henan University of Chinese Medicine,Zhengzhou Henan China 450002;Institute of Hepatology,Henan University of Chinese Medicine,Zhengzhou Henan China 450046)

机构地区：[1]河南中医药大学第二临床医学院,河南郑州450002 [2]河南中医药大学肝病研究所,河南郑州450046

出　　处：《中医学报》2024年第10期2126-2132,共7页Acta Chinese Medicine

基　　金：全国名中医传承工作室建设项目{国中医药办人教函〔2018〕119号};河南省中医药科学研究专项课题资助项目(2022ZY1167);河南省高等学校重点科研项目(21B310003)。

摘　　要：肝纤维化基本病机总属本虚标实、气虚血瘀络阻,与动物类中药补虚、破瘀、通络作用相契合。冬虫夏草、鳖甲、土鳖虫等单味中药或其提取物及相关复方应用广泛,可通过调控相关细胞因子及多种信号通路,如转化生长因子-β1、核因子-κB等,抑制肝星状细胞活化增殖;或调节基质金属蛋白酶、基质金属蛋白酶抑制剂等基因表达,恢复胶原蛋白的生成与降解平衡状态;或阻止病理性血管新生及调节免疫反应等发挥抗肝纤维化作用。The basic pathogenesis of liver fibrosis is the deficiency in root and excess in symptoms as well as Qi deficiency and blood stasis obstruction in collateral,which is consistent with the effects of traditional Chinese medicine animal materials to replenish deficiency,break stasis and clear the collaterals.Dongchongxiacao(Cordyceps sinensis),Biejia(turtle shell)and Tubiechong(Ground beeltle)and other single-flavor traditional Chinese medicines or their extracts and related compounds are widely used in clinic,in regulating related cytokines and a variety of signaling pathways,such as transforming growth factor-β1 and nuclear transcription factor-κB,etc.It can inhibit the activation and proliferation of hepatic stellate cells,or regulate the expression of matrix metalloproteinases and matrix metalloproteinase inhibitors,restore the balance of collagen production and degradation,or prevent pathological angiogenesis and regulate immune responses.

关 键 词：肝纤维化 动物类中药 转化生长因子-Β1 核因子-ΚB 肝星状细胞 基质金属蛋白酶 基质金属蛋白酶抑制剂 

分 类 号：R259.75[医药卫生—中西医结合]