老年糖尿病采用甘精胰岛素+二甲双胍治疗的临床疗效  

Clinical Efficacy of Insulin Glargine+Metformin Therapy in Elderly Dia⁃betes Mellitus

作　　者：马莉 王熙坤 MA Li;WANG Xikun(Qinzhou District People's Hospital,Tianshui 741000,Gansu,China)

机构地区：[1]天水市秦州区人民医院,甘肃天水741000

出　　处：《糖尿病新世界》2024年第13期8-11,共4页Diabetes New World

摘　　要：目的分析老年糖尿病采用甘精胰岛素+二甲双胍治疗的临床疗效。方法回顾性选取2023年1—12月天水市秦州区人民医院内分泌科收治的60例老年糖尿病患者的临床资料,根据不同用药方法分为对照组(予以甘精胰岛素治疗)、观察组(予以甘精胰岛素+二甲双胍治疗),各30例。比较两组糖代谢(空腹血糖、餐后2 h血糖、糖化血红蛋白、胰岛β细胞功能指数、胰岛素抵抗指数)、C肽水平、并发症、不良反应。结果治疗后,两组空腹血糖、餐后2 h血糖、糖化血红蛋白、胰岛素抵抗指数均低于治疗前,且观察组低于对照组,差异有统计学意义(P均<0.05);治疗后,两组胰岛β细胞功能指数高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。治疗后,两组空腹C肽水平、餐后1 h C肽水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P均<0.05)。观察组并发症发生率低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率对比,差异无统计学意义(P>0.05)。结论在甘精胰岛素基础上应用二甲双胍,可显著改善老年糖尿病患者糖代谢状况,降低血糖水平,升高C肽水平,改善患者胰岛功能,有效延缓病情进展,预防并发症,且治疗安全性较高。Objective To analyze the clinical efficacy of insulin glargine+metformin treatment in elderly diabetes mellitus.Methods Clinical data of 60 elderly diabetes mellitus patients admitted to the Endocrinology Department of Qinzhou District People's Hospital in Tianshui from January to December 2023 were retrospectively selected,and they were divided into control group(treated with insulin glargine)and observation group(treated with insulin glargine+metformin)according to different medication methods,with 30 cases in each group.Glucose metabolism(fasting plasma glucose,2-hour postprandial plasma glucose,glycated hemoglobin A1c,isletβcell function index,insulin re⁃sistance index),C-peptide level,complications and adverse reactions were compared between the two groups.Results After treatment,fasting plasma glucose,2-hour postprandial plasma glucose,glycated hemoglobin A1c and homeo⁃static model assessment of insulin resistance in two groups were lower than before treatment,and observation group were lower than control group,and the differences were statistically significant(all P<0.05).After treatment,the ho⁃meostatic model assessment of isletβ-cell function index in two groups were higher than before treatment,and the ob⁃servation group was higher than the control group,and the differences were statistically significant(all P<0.05).After treatment,the fasting C-peptide level and 1-hour postprandial C-peptide level in two groups were higher than before treatment,and the observation group were higher than the control group,and the differences were statistically signifi⁃cant(all P<0.05).The complication rate of observation group was lower than that of control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reac⁃tions between the two groups(P>0.05).Conclusion The application of metformin on the basis of insulin glargine can significantly improve the glucose metabolism of elderly patients with diabetes,reduce blood sug

关 键 词：二甲双胍 甘精胰岛素 老年糖尿病 空腹血糖 胰岛β细胞功能指数 空腹C肽 

分 类 号：R9[医药卫生—药学]