达格列净联合瑞格列奈与甘精胰岛素治疗2型糖尿病的临床效果  

Clinical Effects of Dapagliflozin Combined with Repaglinide and Insulin Glargine in the Treatment of Type 2 Diabetes Mellitus

作　　者：张秀娟 ZHANG Xiujuan(Second Department of Internal Medicine,Zhangdian District Traditional Chinese Medicine Hospital,Zibo 255000,Shandong,China)

机构地区：[1]淄博市张店区中医院内二科,山东淄博255000

出　　处：《糖尿病新世界》2024年第13期92-95,共4页Diabetes New World

摘　　要：目的探究2型糖尿病患者应用达格列净+瑞格列奈+甘精胰岛素治疗的临床效果。方法选取2023年3月—2024年3月淄博市张店区中医院收治的94例2型糖尿病患者作为研究对象,根据不同治疗方法分为一般组、探究组,各47例,一般组行瑞格列奈+甘精胰岛素治疗,探究组在一般组基础上加用达格列净,比较两组血糖指标、血糖波动指标、治疗总有效率及不良反应发生率。结果治疗后,两组空腹血糖、餐后2 h血糖水平均降低,且探究组低于一般组,差异有统计学意义(P均<0.05)。治疗后,两组平均血糖及血糖水平标准差均下降,且探究组低于一般组,差异有统计学意义(P均<0.05)。探究组治疗总有效率为97.87%(46/47),高于一般组的82.98%(39/47),差异有统计学意义(χ^(2)=6.021,P=0.014)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论达格列净+瑞格列奈+甘精胰岛素联合应用的治疗有效率更高,能在降低血糖的基础上调控血糖波动幅度,且不增加不良反应发生率,促进2型糖尿病患者的恢复。Objective To investigate the clinical effect of dapagliflozin+repaglinide+insulin glargine in patients with type 2 diabetes mellitus.Methods A total of 94 patients with type 2 diabetes mellitus admitted to Zhangdian District Traditional Chinese Medicine Hospital in Zibo from March 2023 to March 2024 were selected as the research objects.According to different treatment methods,they were divided into general group and inquiry group,with 47 cases in each group.The general group was treated with repaglinide+insulin glargine,and the inquiry group was treated with dapagliflozin on the basis of the general group.The blood glucose indexes,blood glucose fluctuation indexes,total effective rate of treatment efficiency and incidence of adverse reactions were compared between the two groups.Results After treatment,the levels of fasting plasma glucose,2-hour postprandial plasma glucose in both groups decreased,and those in the inquiry group were lower than the general group,the differences were statistically significant(all P<0.05).After treatment,the mean blood glucose and standard deviation of blood glucose levels in the two groups decreased,and those in the inquiry group were lower than the general group,the differences were statistically significant(both P<0.05).The total effective rate of treatment in the inquiry group was 97.87%(46/47),which was higher than 82.98%(39/47)in the general group,and the difference was statistically significant(χ^(2)=6.021,P=0.014).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of dapagliflozin+repaglinide+insulin glargine is more effective in the treatment of type 2 diabetes mellitus,which can regulate the fluctuation of blood glucose on the basis of reducing blood glucose,and does not increase the incidence of adverse events and promote the recovery of patients with type 2 diabetes mellitus.

关 键 词：达格列净 甘精胰岛素 瑞格列奈 2型糖尿病 

分 类 号：R587.1[医药卫生—内分泌]