某院2017~2022年期间抗感染类药品不良反应报告分析  

Analysis of adverse reaction reports of anti-infective drugs in a hospital from 2017 to 2022

作　　者：朱小明 陈芝 ZHU Xiao-ming;CHEN Zhi(Department of Pharmacy,Sunshine Union Hospital,Weifang 261000,China)

机构地区：[1]阳光融和医院药学部,山东潍坊261000

出　　处：《中国处方药》2024年第9期77-80,共4页Journal of China Prescription Drug

摘　　要：目的 探究某院2017~2022年期间抗感染类药品不良反应发生的相关因素及用药分析。方法 收集2017~2022年期间抗感染类药品不良反应报告500例进行回顾性分析,分析发生不良反应患者的年龄及性别分布、给药途径、发生不良反应的抗感染类药品分布、累及系统/器官及主要临床表现、不良反应报告类型和报告人职业分布等情况,并根据分析结果,提出抗感染类药品的用药启示。结果500例抗感染类药品不良反应患者中,男女比例为1.07:1,平均年龄(50.63±20.87)岁。不良反应给药途径以静脉滴注为主,占比为85.60%。抗感染药品发生不良反应涉及抗感染药品21个类别、89个品种。喹诺酮类142例(28.40%)是排在首位的药品种类。左氧氟沙星42例(8.40%)是排在首位的单品种。抗感染类药品不良反应累及多个系统/器官,占比最高的是全身反应121例(24.20%)。主要临床表现为过敏性休克74例(14.80%)、过敏反应38例(7.60%)、血小板减少36例(7.20%)、肝功能异常29例(5.80%)等。感染类药品不良反应一般460例(92.00%),占比较大,新的及严重的40例(8.00%),占比较小;从报告人的职业角度看,医生报告223例(44.60%),护士报告200例(40.00%),这两类占比较大。结论 本文通过分析抗感染类药品发生不良反应患者的年龄及性别构成、给药途径、发生不良反应药物的类别及品种、累及系统/器官及主要临床表现、不良反应报告类型和报告人职业分布,启示临床在应用抗感染类药品时,一定要严格依据患者的生理特点、具体病情以及疾病病理本身等给予针对性用药,更要重视抗感染药品的给药途径、给药速度,实时监测给药过程中患者的不良反应情况,以避免或减少抗感染类药品不良反应的发生。Objective To explore the related factors and medication implications of adverse reactions of anti-infective drugs in a hospital from 2017 to 2022.Methods A retrospective analysis of 500 cases of anti-infective drug adverse reactions reported in a hospital from 2017 to 2022 was conducted.The age and gender distribution,route of administration,distribution of anti-infective drugs with adverse reactions,and adverse drug reactions were analyzed.Involved systems/organs and main clinical manifestations,types of adverse reactions reported and occupational distribution of reporters,etc.,and based on the analysis results,we put forward the use of anti-infective drugs.Results Among the 500 patients with adverse reactions to anti-infective drugs in a hospital,the male to female ratio was 1.07∶1,and the average age was(50.63±20.87)years old.The main route of administration of adverse reactions was intravenous drip,accounting for 85.60%.The adverse reactions of anti-infective drugs involved 21 categories and 89 varieties of antiinfective drugs.142 cases(28.40%)of quinolones were the top drug category.42 cases(8.40%)of levofloxacin were the single variety in the first place.The adverse reactions of anti-infective drugs involved multiple systems/organs,and systemic reactions accounted for the highest proportion in 121 cases(24.20%).The main clinical manifestations were anaphylactic shock in 74 cases(14.80%),allergic reaction in 38 cases(7.60%),thrombocytopenia in 36 cases(7.20%),and abnormal liver function in 29 cases(5.80%).Infectious drug adverse reactions were generally 460 cases(92.00%),accounting for a relatively large proportion,and 40 new and serious adverse reactions(8.00%),accounting for a relatively small proportion;Doctors reported 223 cases(44.60%),nurses reported 200 cases(40.00%),and these two categories accounted for a larger proportion.Conclusion This article analyzes the age and gender composition,route of administration,type and variety of adverse drug reactions,involved systems/organs and main clinical man

关 键 词：抗感染类药品 药品不良反应 报告分析 

分 类 号：R978[医药卫生—药品]