生物材料表界面地貌结构及理化特性对巨噬细胞的影响及其在创面愈合中的应用研究进展  

Research advance on the effects of surface interface topographies and physicochemical properties of biomaterial on macrophages and their application in wound healing

作　　者：张惟 邵佳鸣 杨敏[3] 柳欢 韩春茂[2] 王新刚[2] Zhang Wei;Shao Jiaming;Yang Min;Liu Huan;Han Chunmao;Wang Xingang(Department of Plastic Surgery,the Second Affiliated Hospital of Zhejiang University School of Medicine,Hangzhou 310009,China;Department of Burn and Wound Repair,the Second Affiliated Hospital of Zhejiang University School of Medicine,Hangzhou 310009,China;Department of Wound Repair,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou 325000,China)

机构地区：[1]浙江大学医学院附属第二医院整形科,杭州310009 [2]浙江大学医学院附属第二医院烧伤与创面修复科,杭州310009 [3]温州医科大学附属第一医院创面修复科,温州325000

出　　处：《中华烧伤与创面修复杂志》2024年第9期891-896,共6页Chinese Journal of Burns And Wounds

基　　金：国家重点研发计划(2022YFC2403100);国家自然科学基金面上项目(82172198)。

摘　　要：人体免疫系统在维持组织稳态和疾病进展中起关键作用。研发可调控先天免疫系统和适应免疫系统的生物材料,在组织工程领域极具应用前景。该文从材料学角度探讨如何设计生物材料的表界面地貌结构或理化特性,从而调控巨噬细胞的命运,如活化、极化、黏附、迁移、增殖和分泌;同时探讨如何将这些具有免疫调控功能的生物材料应用于创面愈合领域。此外,该文还提出生物材料在免疫调控应用中的局限性,并对未来的发展方向进行展望。The human immune system plays a key role in maintaining tissue homeostasis and disease progression.The development of biomaterials that can regulate the innate immune system and adapt to the immune system has great application prospects in the field of tissue engineering.This paper discusses how to design the surface interface topographies or the physicochemical properties of biomaterials,to regulate the fate of macrophages,such as activation,polarization,adhesion,migration,proliferation,and secretion.At the same time,the application of these biomaterials with immunoregulation function in the field of wound healing is discussed.In addition,this paper also put forward the limitations of biomaterials in immunoregulation applications and prospected the future development directions.

关 键 词：巨噬细胞 生物相容性材料 免疫 极化 表界面地貌 创面修复 

分 类 号：R318.08[医药卫生—生物医学工程]