重症肝病伴医院感染患者的病原菌分布及耐药特征分析  

Analysis of pathogenic bacteria detection characteristics and drug sensitivity test results in patients with severe liver disease and hospital infection

作　　者：张婷婷 ZHANG Tingting(Luoyang Sixth People’s Hospital Intensive Care Medicine,Luoyang 471000,Henan,China)

机构地区：[1]洛阳市第六人民医院重症医学科,河南洛阳471000

出　　处：《中国校医》2024年第6期476-479,共4页Chinese Journal of School Doctor

摘　　要：目的探讨重症肝病伴医院感染患者病原菌检出特点及药敏试验结果。方法选取2020年1月-2023年1月我院收治的93例重症肝病伴医院感染患者为研究对象,均采集标本送检,进行病原菌培养及药敏试验,统计病原菌检出特点及主要病原菌耐药性。结果93例患者共检出125株病原菌,其中革兰氏阴性菌73株(58.40%),革兰氏阳性菌46株(36.80%),真菌6株(4.80%);革兰氏阴性菌中大肠埃希菌、肺炎克雷伯菌占比高;革兰氏阳性菌中金黄色葡萄球菌、表皮葡萄球菌占比高;主要革兰氏阴性菌对美罗培南、亚胺培南无耐药性,对头孢唑林、头孢他啶等耐药性高;主要革兰氏阳性菌对万古霉素、利奈唑胺无耐药性,对青霉素、红霉素等耐药性高。结论重症肝病伴医院感染病原菌多为革兰氏阴性菌,需尽早开展药敏试验,针对性用药,以促进感染消退。Objective To explore the characteristics of pathogen detection and drug sensitivity test results in patients with severe liver disease and hospital infection.Methods 93 patients with severe liver disease and hospital infection admitted to our hospital from January 2020 to January 2023 were selected as the research participants.Samples were collected and sent for examination.Pathogen culture and drug sensitivity tests were conducted,and the characteristics of pathogen detection and main pathogen resistance were analyzed.Results A total of 125 pathogenic bacteria were detected in 93 patients,including 73 Gram negative bacteria(58.40%),46 Gram positive bacteria(36.80%),and 6 fungi(4.80%).Escherichia coli and Klebsiella pneumoniae accounted for a high proportion of the Gram negative bacteria;Staphylococcus aureus and Staphylococcus epidermidis accounted for a high proportion of the Gram positive bacteria.The main Gram negative bacteria showed no resistance to meropenem and imipenem,but high resistance to cefazolin,ceftazidime,and other antibiotics.The main Gram positive bacteria were not resistant to vancomycin and linezolid,but showed high resistance to penicillin,erythromycin,and other antibiotics.Conclusion Severe liver disease with hospital infection is mostly caused by Gram negative bacteria,drug sensitivity testing should be carried out as soon as possible and targeted medication should be used to promote the regression of the infection.

关 键 词：重症肝病 医院感染 病原菌 药敏结果 

分 类 号：R446.5[医药卫生—诊断学]