伊伐布雷定敏感性房性心动过速的研究进展  

Ivabradine-Sensitive Atrial Tachycardia

作　　者：杨漫漫 时向民[1] YANG Manman;SHI Xiangmin(The Sixth Medical Center of PLA General Hospital,South China University of Technology,Beijing 100048,China)

机构地区：[1]解放军总医院第六医学中心华南理工大学,北京100048

出　　处：《心血管病学进展》2024年第9期797-801,共5页Advances in Cardiovascular Diseases

基　　金：国防科技创新课题(20-163-02-ZT-008-007-01)。

摘　　要：房性心动过速(房速)是常见的心律失常,部分表现为局灶起源无休止房速,易导致心动过速性心肌病,常规抗心律失常药效果不理想。伊伐布雷定对部分房速敏感,不仅可有效控制心室率,还可促进房速转复及窦性心律的维持,称为伊伐布雷定敏感性房速。心房异位节律点存在类窦房结样组织,以及超极化激活环核苷酸门控阳离子通道介导的I_(f)电流导致自律性增高,是伊伐布雷定敏感性房速的发病机制。现对伊伐布雷定敏感性房速的研究进展做一综述。Atrial tachycardia is one of common tachyarrhythmia,which could present as focal incessant subtype leading to tachycardia-induced cardiomyopathy with poor response to conventional antiarrhythmic drugs.Ivabradine is effective in lowering ventricular response rate or converting and maintaining sinus rhythm for some refractory atrial tachycardia,known as ivabradine-sensitive atrial tachycardia.Nodal-like tissue in ectopic atrial site with the presence of hyperpolarization activated cyclic nucleotidegated cation channel mediated I_(f) current leading to increased autoregulation could be the mechanism of ivabradine-sensitive atrial tachycardia.This anticle rewiews the research progress of ivabradine-sensitive atrial tachycardia.

关 键 词：伊伐布雷定 房性心动过速 I_(f)电流 心动过速性心肌病 

分 类 号：R541.7[医药卫生—心血管疾病]