铁死亡在射血分数保留的心力衰竭中的研究进展  

Ferroptosis in Heart Failure with Preserved Ejection Fraction

作　　者：王一华 蒋玉娇 门冰欣 胡娜娜 张亚苹 张锦[1,2] WANG Yihua;JIANG Yujiao;MEN Bingxin;HU Nana;ZHANG Yaping;ZHANG Jin(The First Clinical College of Medicine,Lanzhou University,Lanzhou 730000,Gansu,China;Department of Cardiology,The First Hospital of Lanzhou University/Key Laboratory of Cardiovascular Diseases of Gansu Province,Lanzhou 730000,Gansu,China)

机构地区：[1]兰州大学第一临床医学院,甘肃兰州730000 [2]兰州大学第一医院心内科/甘肃省心血管疾病重点实验室,甘肃兰州730000

出　　处：《心血管病学进展》2024年第9期816-820,共5页Advances in Cardiovascular Diseases

基　　金：甘肃省自然科学基金(22JR11RA018)。

摘　　要：铁死亡是近年来提出的一种新型细胞死亡方式,是一种铁依赖的、以脂质过氧化物积累为特征的细胞死亡过程,涉及铁代谢、脂质代谢和氨基酸代谢三个过程。细胞内铁超载可通过脂质过氧化、氧化应激、炎症反应等途径对内皮细胞和心肌细胞造成损伤,在射血分数保留的心力衰竭(HFpEF)的病理生理过程中发挥重要作用。现就HFpEF与铁死亡之间可能存在的相关性进行概述,为进一步研究HFpEF发病机制提供可靠的理论依据,以期为其治疗提供新思路。Ferroptosis is a new cell death method proposed in recent years.It is an iron-dependent cell death process characterized by lipid peroxide accumulation,involving iron metabolism,lipid metabolism and amino acid metabolism.Intracellular iron overload can cause damage to endothelial cells and cardiomyocytes through lipid peroxidation,oxidative stress,inflammation and other pathways,and play an important role in the pathological process of heart failure with preserved ejection fraction(HFpEF).In this paper,the possible correlation between HFpEF and ferroptosis was summarized,so as to provide a reliable theoretical basis for further research on the pathogenesis of HFpEF and provide new ideas for its treatment.

关 键 词：铁死亡 铁超载 氧化应激 射血分数保留的心力衰竭 钠-葡萄糖共转运蛋白2抑制剂 

分 类 号：R541.6[医药卫生—心血管疾病]