肠道微生物定植抗性影响B族链球菌定植的研究进展  

A new advance in intestinal microbial colonization resistance affecting group B Streptococcus colonization

作　　者：朱靓[1] 欧阳谭亮 李云鹤 钟樱 薛云新[1] 王岱[1] Zhu Liang;Ouyang Tanliang;Li Yunhe;Zhong Ying;Xue Yunxin;and Wang Dai(State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics,Xiamen University,Xiamen 361102)

机构地区：[1]分子疫苗学和分子诊断学国家重点实验室,厦门大学,厦门361102

出　　处：《中国抗生素杂志》2024年第8期851-859,共9页Chinese Journal of Antibiotics

基　　金：国家自然科学基金(No.81971905,No.82272349);福建省自然科学基金资助项目(No.2023J01040)。

摘　　要：B族链球菌(group B Streptococcus, GBS)可导致孕妇早产、宫内感染和新生儿化脓性脑膜炎、败血症和肺炎等多种疾病甚至死亡。美国疾病预防控制中心指南建议所有孕产妇在孕35~37周应进行GBS筛查,对检测阳性的孕产妇进行产时抗生素预防。使用抗生素会对人体产生副作用且无法预防GBS迟发性感染,随着细菌抗生素耐药逐年严重,探索成本更低、更有效的预防GBS定植感染措施尤为重要。GBS是一种可通过食物传播的人畜共患病病原体,研究其在肠道中的定植至关重要。肠道内共生细菌可通过肠道定植抗性机制抑制肠道病原体的定植和扩张,减少肠道GBS逆行性感染生殖道的风险,具有成为防治GBS的一级预防措施的潜力。本文着重探讨肠道定植抗性对GBS定植感染的影响,以及基于此的益生菌应用。Group B Streptococcus(GBS)can cause premature birth,intrauterine infection in pregnant women,suppurative meningitis,septicemia,pneumonia in newborns and even death.The U.S.Centers for Disease Control and Prevention recommend that all pregnant women should be screened for GBS at 35~37 weeks of gestation,and those who test positive should be given intrauterine antibiotic prophylaxis(IAP).Antibiotics can cause side effects and do not prevent GBS,a late-onset disease.With the increasing antibiotic resistance of bacteria,it is particularly important to explore more effective and cost-effective measures to prevent GBS colonized infections.GBS is a zoonotic pathogen that can be transmitted through food,and it is important to study its colonization in the gut.Intestinal symbiotic bacteria can inhibit the colonization and expansion of intestinal pathogens through an intestinal colonization resistance mechanism,and reduce the risk of retrograde infection of the reproductive tract by GBS.It has the potential to be a primary prevention measure against GBS.This paper focused on the effect of intestinal colonization resistance on GBS colonization infection and the application of probiotics based on this.

关 键 词：GBS 抗生素耐药 肠道定植抗性 益生菌 

分 类 号：Q932[生物学—微生物学] R978.1[医药卫生—药品]