基于临床数据评价新安健脾通痹系列方改善以关节疼痛为主症的风湿病患者感受研究  

Evaluation of Xin'an Jianpi Tongbi Fang Series Based on Clinical Data to Improve the Feeling of Rheumatoid Arthritis Patients with Joint Pain as the Main Symptom

作　　者：方妍妍 刘健[1] 忻凌[1] 李洋 韩琦 李旭 王帆帆 贺明玉 FANG Yan-yan;LIU Jian;XIN Ling;LI Yang;HAN Qi;LI Xu;WANG Fan-fan;HE Ming-yu

机构地区：[1]安徽中医药大学第一附属医院,安徽合肥230031

出　　处：《风湿病与关节炎》2024年第9期14-20,共7页Rheumatism and Arthritis

基　　金：国家中医药管理局高水平中医药重点学科建设项目——中医痹病学(国中医药人教函〔2023〕85号);现代中医内科应用基础与开发研究安徽省重点实验室(2016080503B041);安徽省第12批“115”创新团队(人才办〔2019〕1号);安徽省名中医刘健工作室建设项目(中医药发展秘〔2018〕11号)。

摘　　要：目的:观察新安健脾通痹系列方(XAJPTBF)对以关节疼痛为主症的风湿病患者感受(SPP)的影响。方法:选取2020年5月至2022年12月安徽中医药大学第一附属医院风湿免疫科以关节疼痛为主症的风湿病出院患者资料,XAJPTBF包括新风胶囊(XFC)、黄芩清热除痹胶囊(HQC)、五味温通除痹胶囊(WWT),根据是否使用XAJPTBF分为XAJPTBF组与Non-XAJPTBF组。采用倾向评分匹配法匹配XAJPTBF组与Non-XAJPTBF组的基线数据,随机行走评价2组改善SPP量表指标及临床炎症指标改善情况的影响,关联规则分析XAJPTBF与指标改善的关联度,Logistic回归分析XAJPTBF对指标改善的评估。结果:共筛选出有完整SPP量表及临床炎症指标的风湿病患者1957例。倾向评分匹配后,XAJPTBF组与Non-XAJPTBF组的基线数据一致,各790例。回顾性数据挖掘结果显示,XAJPTBF可显著降低患者的视觉模拟评分法(VAS)评分、红细胞沉降率(ESR)、C反应蛋白(CRP),升高生理职能(RP)评分,随机行走结果提示XAJPTBF与VAS评分、ESR、CRP、RP的改善长程关联,且改善程度优于Non-XAJPTBF组。关联规则分析结果显示,HQC、XFC分别与VAS评分、SAS、SDS、ESR、CRP指标下降的关联度较高,与RP指标上升的关联度较高(支持度>10%,置信度>50%,提升度>1)。与未使用XAJPTBF患者相比,XFC与指标VAS评分、SAS、ESR、CRP未改善呈负相关(P<0.05),HQC与指标VAS评分、SAS、SDS、ESR、CRP未改善呈负相关(P<0.05)。结论:XAJPTBF可缓解以关节疼痛为主症的风湿病患者关节疼痛症状及炎症反应,改善患者感受。Objective:To observe the effect of the Xin'an Jianpi Tongbi Fang(XAJPTBF)series on the feeling of RA patients with joint pain as the main symptom.Methods:Data of discharged patients with rheumatic diseases(including rheumatoid arthritis,osteoarthritis,ankylosing spondylitis,and gouty arthritis)with joint pain as the main symptom from the Department of Rheumatology and Immunology of the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine from May 2020 to December 2022 were retrieved—XAJPTBF series including Xinfeng Capsule(XFC),Huangqin Qingre Chubi Capsule(HQC)and Wuwei Wentong Chubi Capsule(WWC)—and were divided into the XAJPTBF group and the Non-XAJPPTBF group according to whether XAJPTBF was used or not.The propensity score matching method was used to match baseline data between the XAJPTBF group and the Non-XAJPPTBF group.Random walking was used to evaluate the impact of improving SPP scale indicators and clinical inflammation indicators in both groups.Association rule analysis was used to determine the correlation between XAJPTBF and indicator improvement,and logistic regression analysis was used to evaluate the impact of XAJPTBF on indicator improvement.Results:A total of 1957 rheumatic patients with complete SPP scales and clinical inflammatory indicators were screened out.After propensity score matching,the baseline data of XAJPTBF group and Non-XAJPPTBF group were consistent,with 790 cases in each group.Retrospective data mining results showed that XAJPTBF can significantly reduce patients'VAS,ESR,CRP,and increase RP scores.Random walking results suggest a long-term association between XAJPTBF and improvements in VAS,ESR,CRP,and RP,and the degree of improvement is better than that of the Non-XAJPPTBF group.The analysis of association rules shows that HQC and XFC have a high correlation with the decrease of VAS score,and SAS,SDS,ESR,and CRP indicators,and a high correlation with the increase of RP indicators(support>10%,confidence>50%,improvement>1).Compared with patients who

关 键 词：风湿病 新安健脾通痹系列方 新风胶囊 黄芩清热除痹胶囊 五味温通除痹胶囊 关节疼痛 患者感受 

分 类 号：R259[医药卫生—中西医结合]