基于涎腺超声评估补肾润燥方治疗原发性干燥综合征的疗效  

Evaluation of the Therapeutic Effect of Bushen Runzao Fang(补肾润燥方)on Primary Sjögren's Syndrome Based on Salivary Gland Ultrasound

作　　者：陆冬晴 吴凡[2] 潘新[2] LU Dong-qing;WU Fan;PAN Xin

机构地区：[1]北蔡社区卫生服务中心,上海201204 [2]上海中医药大学附属曙光医院,上海200021

出　　处：《风湿病与关节炎》2024年第9期25-29,35,共6页Rheumatism and Arthritis

基　　金：上海市浦东新区卫生健康委员会“浦东新区国家中医药发展综合改革试验区”专项基金资助项目(PDZY2021-0308);浦东新区中医药传承创新发展示范试点项目建设(中西医结合旗舰社区卫生服务中心-YC-2023-0408)。

摘　　要：目的:通过运用涎腺超声技术评估补肾润燥方治疗肝肾阴虚型原发性干燥综合征累及涎腺的临床疗效,进而探索涎腺超声技术评估中医药治疗原发性干燥综合征疗效的作用。方法:将78例原发性干燥综合征患者随机分为治疗组和对照组,每组39例。对照组服用硫酸羟氯喹,治疗组在此基础上加用补肾润燥方。2组疗程均为12周。观察2组治疗前后ESSDAI评分、中医证候积分、超声半定量分级、剪切波弹性模量。结果:2组各脱落1例,最终每组纳入38例。治疗后,2组ESSDAI评分较治疗前下降(P<0.05);且治疗组下降程度优于对照组(P<0.05)。治疗组临床痊愈0例,显效10例,有效25例,无效3例,总有效率为92.10%;对照组临床痊愈0例,显效3例,有效25例,无效10例,总有效率为73.68%。2组比较,差异有统计学意义(P<0.05)。治疗后,2组涎腺超声半定量分级均有所改善,治疗组改善率为73.68%,对照组改善率为47.37%(P<0.05);2组4个腺体的剪切波弹性模量较治疗前均下降(P<0.05),且治疗组下降程度优于对照组(P<0.05)。结论:补肾润燥方对肝肾阴虚型原发性干燥综合征累及涎腺的患者疗效确切,涎腺超声可以协助评估中医药治疗原发性干燥综合征疗效。Objective:To evaluate the clinical efficacy of Bushen Runzao Fang(补肾润燥方)in treating primary Sjögren's syndrome with liver kidney yin deficiency involving the salivary glands using salivary gland ultrasound technology,and to explore the role of salivary gland ultrasound technology in evaluating the efficacy of traditional Chinese medicine in treating primary Sjögren's syndrome.Methods:Seventy-eight patients with primary Sjögren's syndrome were randomly divided into a treatment group and a control group,with thirty-nine cases in each.The control group was given hydroxychloroquine sulfate,while the treatment group was treated with Bushen Runzao Fang based on the treatment like that for the control group.The treatment course for both groups is 12 weeks.The ESSDAI score,TCM syndrome score,ultrasound semi quantitative grading,and shear wave elastic modulus before and after treatment in both groups were observed.Results:One case fell out of each group,and 38 cases were ultimately included in each.After treatment,the ESSDAI scores of both groups decreased compared to before treatment(P<0.05);and the degree of decline in the treatment group was better than that in the control group(P<0.05).In the treatment group,no cases were clinically cured,10 cases showed significant improvement,25 cases were effective,and 3 cases were ineffective,with a total effective rate of 92.10%;in the control group,there were no cases clinically cured,3 cases showed significant improvement,25 cases were effective,and 10 cases were ineffective,with a total effective rate of 73.68%.The difference between the two groups was statistically significant(P<0.05).After treatment,salivary gland ultrasound semi quantitative grading of both groups showed improvement,with an improvement rate of 73.68%in the treatment group and 47.37%in the control group(P<0.05);the shear wave elastic modulus of four glands in both groups decreased compared to before treatment(P<0.05),and the degree of decrease in the treatment group was better than that in the c

关 键 词：原发性干燥综合征 涎腺超声 补肾润燥方 临床观察 

分 类 号：R259[医药卫生—中西医结合]