Mendelian randomization analysis of causal relationship between cheese intake and diabetic retinopathy  

作　　者：Cheng-Ye Tang Dong-Yong Tang Ying-Qin Yang Yu-Bing Liang Hao Liang 

机构地区：[1]Department of Ophthalmology,the First Affiliated Hospital of Guangxi Medical University,Nanning 530000,Guangxi Zhuang Autonomous Region,China [2]Department of Ophthalmology,the Affiliated Hospital of Guilin Medical University,Guilin 541001,Guangxi Zhuang Autonomous Region,China [3]Department of Anesthesiology,Guangxi Medical University Cancer Hospital,Nanning 530000,Guangxi Zhuang Autonomous Region,China

出　　处：《International Journal of Ophthalmology(English edition)》2024年第10期1905-1910,共6页国际眼科杂志（英文版）

基　　金：Supported by the National Natural Science Foundation of China(No.81960174);the Natural Science Foundation of Guangxi Zhuang Autonomous Region(No.2023GXNSFAA026154);the Youth Science Foundation of Guangxi Medical University(No.GXMUYSF201912).

摘　　要：AIM:To assess whether there is a possible causal link between the intake of cheese and the risk of diabetic retinopathy(DR)utilizing a two-sample Mendelian randomization(MR)analysis.METHODS:The research data were obtained from summary statistics of genome-wide association studies(GWAS).Genetic loci closely related to cheese intake were extracted as instrumental variables(IVs),and DR was the outcome variable.The data were extracted from individuals of European ethnicity.The data of cheese intake consisted of 451486 samples with 9851867 single nucleotide polymorphisms(SNPs),while the DR data consisted of 206234 samples with 16380446 SNPs.Sixty-one genetic loci closely related to cheese intake were selected as IVs.MR analysis was performed by inverse-variance weighted(IVW)method and MR-Egger regression respectively.The causal relationship between cheese intake and DR was evaluated using odds ratios(ORs)and 95%confidence intervals(CIs).Egger-intercept test was used to test horizontal pleiotropy and sensitivity analysis was performed by leave-one-out test.RESULTS:The P value of the IVW method was less than 0.05,indicating a significant negative correlation between cheese intake and DR.MR-Egger regression showed that the intercept was 0.01 with a standard error of 0.022,and a P-value of 0.634,indicating no evidence of horizontal pleiotropy affecting the IVs related to the exposure factors.Besides,heterogeneity tests confirmed the absence of heterogeneity,and the“leave-one-out”sensitivity analysis demonstrated that the results were stable.CONCLUSION:Cheese intake is causally negatively correlated with the occurrence of DR,and cheese intake could reduce the risk of DR.

关 键 词：cheese intake diabetic retinopathy Mendelian randomization analysis 

分 类 号：R587.2[医药卫生—内分泌] R774.1[医药卫生—内科学]