肾移植术后IgA肾病复发的治疗进展  

Research advances on treatment of recurrent IgA nephropathy after kidney transplantation

作　　者：陈柯文 刘金海 张培 余俊豪 隋明星 曾力 Chen Kewen;Liu Jinghai;Zhang Pei;Yu Junhao;Sui Mingxing;Zeng Li(Department of Organ Transplantation,First Affiliated Hospital,Naval Medical University,Shanghai 200433,China;Department of Anesthesiology,First Affiliated Hospital,Naval Medical University,Shanghai 200433,China)

机构地区：[1]海军军医大学第一附属医院器官移植中心,上海200433 [2]海军军医大学第一附属医院麻醉科,上海200433

出　　处：《中华器官移植杂志》2024年第9期636-640,共5页Chinese Journal of Organ Transplantation

基　　金：国家自然科学基金(81700548);海军军医大学三航起航人才项目(QH2022)。

摘　　要：IgA肾病(IgA nephropathy,IgAN)是一类以免疫复合物沉积在肾小球系膜和部分毛细血管袢为基础的肾小球肾炎,也是导致终末期肾病的重要危险因素。肾移植是终末期肾脏衰竭患者的最终治疗手段,但移植后仍有复发风险,且目前尚无有效的复发性IgAN防治方案。本文现就肾移植术后IgAN复发的最大优化疗法、免疫抑制治疗、补体治疗和手术治疗等的最新进展作一综述。IgA nephropathy(IgAN)is one common type of glomerulonephritis caused by a deposition of immune complexes in mesangium and partial capillary loops.It is also an important risk factor for end-stage renal disease(ESRD).Kidney transplantation(KT)has been an ultimate treatment for IgAN patients progressing into ESRD.However,there is still a high risk of recurrence after transplantation.Currently no effective treatment is available for recurrent IgAN.This review summarized the latest researches of managing IgAN recurrence after KT,such as optimal treatment,immunosuppression,complement therapy and surgery.

关 键 词：肾移植 IGA肾病 复发 类固醇 免疫抑制药 

分 类 号：R699.2[医药卫生—泌尿科学]