1例儿童氨氯地平中毒致死病例报告并文献复习  

A case report on a fatal amlodipine poisoning in a child and literature review

作　　者：杜春燕[1] 刘福[1] Du Chunyan;Liu Fu(Department of Pediatrics,Mianyang Central Hospital,Mianyang 621000,China)

机构地区：[1]绵阳市中心医院儿科,四川绵阳621000

出　　处：《实用药物与临床》2024年第9期689-694,共6页Practical Pharmacy and Clinical Remedies

摘　　要：1例14岁儿童分次自服560 mg氨氯地平,随后出现头晕、烦躁不安、恶心、呕吐、气促,考虑氨氯地平中毒。予以洗胃、扩容,静脉给予大剂量去甲肾上腺素及肾上腺素、葡萄糖酸钙,血浆置换、呼吸机辅助呼吸等综合抢救治疗,但最终抢救无效死亡。本文对氨氯地平中毒相关文献进行复习,进一步分析氨氯地平中毒的发病机制及治疗进展,以期为氨氯地平中毒的治疗提供参考。A 14-year-old female adolescent took 560 mg of amlodipine in divided doses by herself.Dizziness,restlessness,nausea,vomiting,and shortness of breath ensued.It was considered to be amlodipine poisoning.Gastric lavage,volume expansion,high-dose norepinephrine and epinephrine,calcium gluconate,plasma exchange,ventilatorassisted respiration and other comprehensive rescue treatments were given,but ultimately the rescue failed and she died.The literatures related to amlodipine poisoning were reviewed to further analyze the pathogenesis and therapeutic progress on amlodipine poisoning,in order to provide reference for the treatment of amlodipine poisoning.

关 键 词：氨氯地平 中毒 儿童 发病机制 

分 类 号：R725.9[医药卫生—儿科]