环泊酚应用于颅内动脉瘤栓塞术的效果  

Effects of ciprofol in intracranial aneurysm embolization

作　　者：梅凤美[1] 曾琼[1] 陆军[1] 阮义峰[1] 吴姗姗[1] MEI Feng-mei;ZENG Qiong;LU Jun;RUAN Yi-feng;WU Shan-shan(Department of Anesthesiology,Affiliated Brain Hospital of Nanjing Medical University,Nanjing JIANGSU 210029,China)

机构地区：[1]南京医科大学附属脑科医院麻醉科,江苏南京210029

出　　处：《中国新药与临床杂志》2024年第8期607-611,共5页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：目的观察环泊酚在颅内动脉瘤栓塞术中的麻醉效果。方法选择择期行颅内动脉瘤栓塞术的患者120例,ASA分级Ⅰ~Ⅱ级,随机分为对照组和试验组,每组60例。麻醉诱导时采用咪达唑仑0.04 mg·kg^(-1)、舒芬太尼0.25μg·kg^(-1)、环泊酚0.4 mg·kg^(-1)(试验组)或丙泊酚2.0 mg·kg^(-1)(对照组)及罗库溴铵0.6 mg·kg^(-1)。麻醉维持2组均持续泵注瑞芬太尼1μg·kg^(-1)·h^(-1)、顺阿曲库铵0.1 mg·kg^(-1)·h^(-1),试验组加用环泊酚0.8 mg·kg^(-1)·h^(-1),对照组加用丙泊酚5 mg·kg^(-1)·h^(-1)。术中调整泵注速度使脑电双频指数(BIS)维持在40~60,观察生命体征和BIS的变化,记录麻醉诱导时间﹑苏醒时间﹑拔管后Ramsay镇静评分等,观察不良反应发生情况。结果2组麻醉前、麻醉诱导后、气管插管后、手术结束时、气管导管拔除后各观察时点收缩压(SBP)﹑舒张压(DBP)和心率(HR)比较,均无显著差异(P>0.05),试验组手术结束时的BIS显著低于对照组(P<0.05)。麻醉诱导期间对照组SBP﹑DBP和HR的波动值显著大于试验组(P<0.05)。试验组苏醒时间长于对照组,镇静药物总用量少于对照组,均有显著差异(P<0.05)。试验组麻醉诱导后低血压﹑插管后高血压以及注射痛的发生率显著低于对照组(P<0.05)。结论环泊酚应用于颅内动脉瘤栓塞术具有良好的镇静效果,患者术中血流动力学波动更趋平稳,术后不良反应发生率低。AIM To observe the anesthetic effect of ciprofol in intracranial aneurysm embolization.METHODS One hundred and twenty patients undergoing intracranial aneurysm embolization,ASAⅠorⅡ,were randomly divided into control group and experimental group(n=60,each group).During anesthesia induction,patients were given with midazolam 0.04 mg·kg^(-1),sufentanil 0.25μg·kg^(-1),ciprofol 0.4 mg·kg^(-1)(experimental group)or propofol 2.0 mg·kg^(-1)(control group),and rocuronium 0.6 mg·kg^(-1).During anesthesia maintenance,all patients were maintained with remifentanil 1μg·kg^(-1)·h^(-1)and cisatracurium 0.1 mg·kg^(-1)·h^(-1),combined with ciprofol 0.8 mg·kg^(-1)·h^(-1)(experimental group)or propofol 5 mg·kg^(-1)·h^(-1)(control group).The bispectral index(BIS)was maintained between 40 and 60 by adjusting the pumping speed during the operation.The changes of vital signs and BIS were observed.The anesthesia induction time,awakening time,and Ramsay sedation score after extubation were recorded.And the occurrence of adverse reactions was also observed.RESULTS There was no significant difference in systolic blood pressure(SBP),diastolic blood pressure(DBP),and heart rate(HR)between the two groups before anesthesia,after anesthesia induction,after tracheal intubation,at the end of operation,and after tracheal extubation.The BIS at the end of operation in the experimental group was lower than that in the control group(P<0.05).The fluctuation value of SBP,DBP,and HR during anesthesia induction in the control group was significantly greater than that in the experimental group(P<0.05).The recovery time of the experimental group was slightly longer while the use of sedatives was less than that of the control group(P<0.05).The incidences of post-induced hypotension,hypertension after intubation,and injection pain in the experimental group were lower than those in the control group(P<0.05).CONCLUSION Ciprofol can be used in intracranial aneurysm embolization with outstanding sedative efficacy.The hemodynamics of patient is

关 键 词：环泊酚 丙泊酚 颅内动脉瘤 栓塞 治疗性 

分 类 号：R691[医药卫生—泌尿科学]