温肾益心方辅助心脉隆注射液对老年冠心病合并心力衰竭患者的治疗效果  

Treatment Efficacy of Wenshen Yixin Decoction Assisted Xinmailong Injection in Elderly Coronary Heart Disease Patients Complicated with Heart Failure

作　　者：徐雪梅 李凤娥 苏萍 刘薇 XU Xuemei;LI Feng'e;SU Ping;LIU Wei(Department of Cardiology,Tangshan Hospital of Traditional Chinese Medicine,Tangshan 063000,China)

机构地区：[1]河北省唐山市中医医院心血管二科,063000

出　　处：《实用心脑肺血管病杂志》2024年第10期100-104,共5页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

基　　金：河北省中医药管理局科研项目(2022286)。

摘　　要：目的探究温肾益心方辅助心脉隆注射液对老年冠心病(CHD)合并心力衰竭(HF)患者的治疗效果。方法选取2021年7月—2023年7月于唐山市中医医院接受治疗的老年CHD合并HF患者112例,采用随机数字表法将其分为对照组和观察组,每组56例。所有患者接受新四联方案治疗,对照组接受心脉隆注射液治疗,观察组在对照组基础上接受温肾益心方治疗。比较两组临床疗效和治疗前后中医证候积分、心功能指标〔包括心排血量(CO)、左心室射血分数(LVEF)、每搏输出量(SV)〕、6 min步行距离(6MWD)、血清心肌肌钙蛋白I(cTnI)、血清N末端脑钠肽前体(NT-proBNP)、血清可溶性肿瘤生成抑制因子2(sST2)及治疗期间不良反应发生率。结果对照组剔除3例患者,其中中途自行换药1例、未按要求服药2例。观察组剔除3例患者,其中中途自行换药1例、未按要求服药1例、失访1例。观察组临床疗效优于对照组(P<0.05)。治疗后,两组心悸、乏力、喘息、气短积分分别低于本组治疗前,且观察组心悸、乏力、喘息、气短积分低于对照组(P<0.05)。治疗后,两组CO、LVEF、SV分别高于本组治疗前,6MWD分别长于本组治疗前,且观察组CO、LVEF、SV高于对照组,6MWD长于对照组(P<0.05)。治疗后,两组血清cTnI、NT-proBNP、sST2分别低于本组治疗前,且观察组血清cTnI、NT-proBNP、sST2低于对照组(P<0.05)。两组治疗期间不良反应发生率比较,差异无统计学意义(P>0.05)。结论温肾益心方辅助心脉隆注射液可提高老年CHD合并HF患者临床疗效,减轻患者症状,提高患者心功能及运动耐量,降低HF生物标志物水平,且用药安全性较高。Objective To investigate the treatment efficacy of Wenshen Yixin decoction assisted Xinmailong injection in elderly coronary heart disease(CHD)patients complicated with heart failure(HF).Methods A total of 112 elderly CHD patients complicated with HF who were treated in Tangshan Hospital of Traditional Chinese Medicine from July 2021 to July 2023 were selected.According to the random number table method,they were divided into the control group and the observation group,with 56 cases in each group.All patients were treated with new quadruple regimen.The control group was treated with Xinmailong injection,and the observation group was treated with Wenshen Yixin decoction on the basis of the control group.The clinical efficacy,and traditional Chinese medicine syndrome scores,cardiac function indexes[including cardiac output(CO),left ventricular ejection fraction(LVEF),stroke volume(SV)],6 minutes walking distance(6MWD),serum cardiac troponin I(cTnI),serum N-terminal pro-brain natriuretic peptide(NT-proBNP),and serum soluble suppression of tumorigenicity 2(sST2)before and after treatment,and incidence of adverse reactions during the treatment were compared between the two groups.Results In the control group,3 cases were excluded,including 1 case of self-changing dressing and 2 cases of not taking medicine as required.In the observation group,3 cases were excluded,including 1 case of self-changing dressing,1 case of not taking medicine as required,and 1 case of loss of follow-up.The clinical efficacy of the observation group was better than that of the control group(P<0.05).After treatment,the scores of palpitation,fatigue,wheezing and shortness of breath in the two groups were lower than those before treatment respectively,and the scores of palpitation,fatigue,wheezing and shortness of the observation group were lower than those of the control group(P<0.05).After treatment,the CO,LVEF and SV of the two groups were higher than those before treatment,and the 6MWD was longer than that before treatment,respectively,and t

关 键 词：冠心病 心力衰竭 心脉隆注射液 温肾益心方 治疗结果 

分 类 号：R541.4[医药卫生—心血管疾病] R541.62[医药卫生—内科学]