糖代谢重编程对动脉粥样硬化斑块炎症反应影响的研究进展  

Research Progress of the Effect of Glycometabolic Reprogramming on Inflammatory Response of Atherosclerotic Plaque

作　　者：杜晓诗 李哲 赵亚庆 徐静雯 高梅 DU Xiaoshi;LI Zhe;ZHAO Yaqing;XU Jingwen;GAO Mei(The Second Clinical College of Shandong University of Traditional Chinese Medicine,Jinan 250014,China;Department of Cardiology,the First Affiliated Hospital of Shandong First Medical University/Shandong Provincial Qianfoshan Hospital/Shandong Medicine and Health Key Laboratory of Cardiac Electrophysiology and Arrhythmia,Jinan 250014,China)

机构地区：[1]山东中医药大学第二临床医学院,山东省济南市250014 [2]山东第一医科大学第一附属医院,山东省千佛山医院心血管内科,山东省医药卫生心律失常重点实验室,山东省济南市250014

出　　处：《实用心脑肺血管病杂志》2024年第10期132-136,140,共6页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

基　　金：国家自然科学基金资助项目(82205061);中国博士后科学基金资助项目(2022M711979)。

摘　　要：动脉粥样硬化(AS)是一种慢性炎症性疾病,其中免疫细胞和致炎因子在斑块的形成过程中发挥着重要作用。代谢重编程是细胞代谢发生变化的统称,其反映了细胞对环境变化的适应性调节。代谢重编程涉及糖、脂、氨基酸等多种代谢途径的变化,其中糖代谢改变是重编程的能量基础和物质核心。在AS的病理过程中,大量的细胞需要通过糖代谢重编程来满足急剧增加的能量需求,而该过程产生的中间代谢物质诱导了局部细胞的适应性调节并分泌大量的活性因子,从而加剧AS的炎症反应。本文就糖代谢重编程对AS斑块炎症反应的影响进行综述,以期为AS的研究提供新的思路和方向。Atherosclerosis(AS)is a chronic inflammatory disease.Immune cells and inflammatory factors play important role in plaque formation.Metabolic reprogramming is a general term for the changes in cell metabolism,which reflects the adaptive regulation of cells to environmental changes.Metabolic reprogramming involves the changes of various metabolic pathways such as sugars,lipids and amino acids,among which the changes of sugars metabolism are the energy base and material core of reprogramming.In the pathological process of AS,a large number of cells need to meet the dramatically increased energy demand through the reprogramming of glucose metabolism.The intermediate metabolic substances generated in this process induce the adaptive regulation of local cells and secrete a large number of active factors,and aggravate the inflammatory response of AS.In this paper,the effect of glycometabolic reprogramming on inflammatory response of AS plaques was reviewed so as to provide new ideas and directions for the study of AS.

关 键 词：动脉粥样硬化 糖代谢重编程 柠檬酸循环 磷酸戊糖途径 综述 

分 类 号：R543.5[医药卫生—心血管疾病]