血清CCL11水平与T2DM合并冠状动脉粥样硬化性心脏病的相关性  

Correlation between serum CCL11 level and T2DM complicated with coronary atherosclerotic heart disease

作　　者：王晨鸽 李艳萍 Wang Chenge;Li Yanping(Cardiovascular Department,Shangluo Central Hospital,Shangluo 726000,China)

机构地区：[1]商洛市中心医院心血管内科,商洛726000

出　　处：《国际医药卫生导报》2024年第20期3402-3406,共5页International Medicine and Health Guidance News

基　　金：陕西省重点研发计划(2021SF-319)。

摘　　要：目的探讨血清CC趋化因子配体11(CCL11)水平与2型糖尿病(T2DM)合并冠状动脉粥样硬化性心脏病(CAD)的相关性。方法选取2022年1月至2024年4月商洛市中心医院收治的T2DM患者146例,按照是否合并CAD分为合并CAD组(CAD组)70例及单纯T2DM组(T2DM组)76例。CAD组中男43例,女27例,年龄(61.53±8.24)岁;T2DM组中男42例,女34例,年龄(59.30±6.86)岁。收集两组一般临床资料,检测血清CCL11水平及相关代谢指标。采用t检验、χ^(2)检验。结果CAD组T2DM病程长于T2DM组[(7.41±3.12)年比(6.08±2.58)年],低密度脂蛋白胆固醇(LDL-C)和血清CCL11水平均高于T2DM组[(3.06±1.01)mmol/L比(2.60±0.78)mmol/L、(65.53±21.28)ng/L比(46.47±18.36)ng/L],差异均有统计学意义(t=2.815、3.094、5.807,均P<0.05)。二元logistic回归分析结果显示,T2DM病程长、高LDL-C和血清CCL11水平均是T2DM合并CAD的危险因素(均P<0.05)。受试者操作特征曲线(ROC)分析显示,血清CCL11水平诊断T2DM合并CAD的曲线下面积(AUC)为0.751,灵敏度为65.7%,特异度为78.9%,约登指数为0.446。结论T2DM病程长、高LDL-C和血清CCL11水平均是T2DM合并CAD的独立危险因素;血清CCL11水平对预测T2DM合并CAD具有较好的诊断价值。Objective To investigate the correlation between serum CC chemokine ligand 11(CCL11)level and type 2 diabetes mellitus(T2DM)complicated with coronary atherosclerotic heart disease(CAD).Methods A total of 146 T2DM patients admitted to Shangluo Central Hospital from January 2022 to April 2024 were selected and were divided into a CAD group(70 patients)and a T2DM group(76 patients)according to whether they were complicated with CAD or not.In the CAD group,there were 43 males and 27 females,aged(61.53±8.24)years.In the T2DM group,there were 42 males and 34 females,aged(59.30±6.86)years.The general clinical data of the two groups were collected,and the serum CCL11 level and related metabolic indicators were detected.t test andχ^(2)test were used.Results The duration of diabetes in the CAD group was longer than that in the T2DM group[(7.41±3.12)years vs.(6.08±2.58)years],and the levels of low density lipoprotein cholesterol(LDL-C)and serum CCL11 were higher than those in the T2DM group[(3.06±1.01)mmol/L vs.(2.60±0.78)mmol/L,(65.53±21.28)ng/L vs.(46.47±18.36)ng/L],with statistically significant differences(t=2.815,3.094,and 5.807,all P<0.05).Binary logistic regression analysis showed that long duration of diabetes,high LDL-C and serum CCL11 levels were risk factors for CAD in T2DM patients(all P<0.05).The receiver operator characteristic curve(ROC)analysis showed that the area under the curve(AUC)of serum CCL11 level for diagnosing T2DM with CAD was 0.751,the sensitivity was 65.7%,the specificity was 78.9%,and the Youden index was 0.446.Conclusions Long duration of diabetes,high LDL-C and serum CCL11 levels are independent risk factors for T2DM complicated with CAD.Serum CCL11 level has good diagnostic value in predicting T2DM complicated with CAD.

关 键 词：2型糖尿病 冠状动脉粥样硬化性心脏病 CCL11 相关性 危险因素 

分 类 号：R587.1[医药卫生—内分泌] R541.4[医药卫生—内科学]